Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells
DC Field | Value | Language |
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dc.contributor.author | Oh, Yeon-Kyung | - |
dc.contributor.author | Jang, Eunkyeong | - |
dc.contributor.author | Paik, Doo-Jin | - |
dc.contributor.author | Youn, Jeehee | - |
dc.date.accessioned | 2022-07-15T22:31:42Z | - |
dc.date.available | 2022-07-15T22:31:42Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157078 | - |
dc.description.abstract | Early growth response (Egr)-1 is a Cys₂-His₂-type zinc-finger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in the differentiation of B cells into plasma cells remains unclear. To examine the effects of Egr-1 deficiency on the activation of B cells, naive B cells from Egr1⁻/⁻mice and their wild-type (WT) littermates were activated to proliferate and differentiate, and then assayed by FACS. Proportions of cells undergoing proliferation and apoptosis did not differ between Egr1⁻/⁻and WT mice. However, Egr1⁻/⁻B cells gave rise to fewer plasma cells than WT B cells. Consistently, Egr1⁻/⁻mice produced significantly lower titer of antigen-specific IgG than their WT littermates upon immunization. Our results demonstrate that Egr-1 participates in the differentiation program of B cells into plasma cells, while it is dispensable for the proliferation and survival of mature B cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | - |
dc.title | Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.doi | 10.4110/in.2015.15.3.161 | - |
dc.identifier.wosid | 000421270800007 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, v.15, no.3, pp.161 - 166 | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.citation.title | IMMUNE NETWORK | - |
dc.citation.volume | 15 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 166 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002005789 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordAuthor | Egr1 | - |
dc.subject.keywordAuthor | B cells | - |
dc.subject.keywordAuthor | Plasma cells | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Antibody | - |
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