Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cellsopen access
- Authors
- Oh, Yeon-Kyung; Jang, Eunkyeong; Paik, Doo-Jin; Youn, Jeehee
- Issue Date
- Jun-2015
- Publisher
- KOREA ASSOC IMMUNOLOGISTS
- Keywords
- Egr1; B cells; Plasma cells; Differentiation; Antibody
- Citation
- IMMUNE NETWORK, v.15, no.3, pp.161 - 166
- Indexed
- SCIE
KCI
- Journal Title
- IMMUNE NETWORK
- Volume
- 15
- Number
- 3
- Start Page
- 161
- End Page
- 166
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157078
- DOI
- 10.4110/in.2015.15.3.161
- ISSN
- 1598-2629
- Abstract
- Early growth response (Egr)-1 is a Cys₂-His₂-type zinc-finger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in the differentiation of B cells into plasma cells remains unclear. To examine the effects of Egr-1 deficiency on the activation of B cells, naive B cells from Egr1⁻/⁻mice and their wild-type (WT) littermates were activated to proliferate and differentiate, and then assayed by FACS. Proportions of cells undergoing proliferation and apoptosis did not differ between Egr1⁻/⁻and WT mice. However, Egr1⁻/⁻B cells gave rise to fewer plasma cells than WT B cells. Consistently, Egr1⁻/⁻mice produced significantly lower titer of antigen-specific IgG than their WT littermates upon immunization. Our results demonstrate that Egr-1 participates in the differentiation program of B cells into plasma cells, while it is dispensable for the proliferation and survival of mature B cells.
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