Effect of intragastric injection of botulinum toxin A for the treatment of obesity: a meta-analysis and meta-regression.
DC Field | Value | Language |
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dc.contributor.author | Bang, Chang Seok | - |
dc.contributor.author | Baik, Gwang Ho | - |
dc.contributor.author | Shin, In Soo | - |
dc.contributor.author | Kim, Jin Bong | - |
dc.contributor.author | Suk, Ki Tae | - |
dc.contributor.author | Yoon, Jai Hoon | - |
dc.contributor.author | Kim, Yeon Soo | - |
dc.contributor.author | Kim, Dong Joon | - |
dc.date.accessioned | 2022-07-15T22:50:01Z | - |
dc.date.available | 2022-07-15T22:50:01Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0016-5107 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157214 | - |
dc.description.abstract | Background Controversies persist regarding the effect of intragastric injection of botulinum toxin A for the treatment of obesity. Objective To assess the efficacy of intragastric botulinum toxin injection for the treatment of obesity. Design A systematic literature review was conducted by using the core databases. Pre-and posttreatment body weight data were extracted and analyzed by using Hedges' g. A random-effects model was applied. The methodological quality of the enrolled studies was assessed by the risk of bias table and Newcastle-Ottawa Scale. Publication bias was evaluated via the funnel plot, trim and fill method, Egger's test, and rank correlation test. Setting Meta-analysis of 8 studies. Patients A total of 115 patients (79 treated vs 36 placebo). Intervention Intragastric botulinum toxin A injection. Main Outcome Measurements Hedges' g, calculated from pre-and posttreatment body weight data and comparison of body weight changes between treatment and placebo group. Results The treatment group was associated with weight loss in a pre/post comparative approach and compared with the placebo group (Hedges' g:-0.443; 95% confidence interval,-0.845 to-0.040; P =.031; and Hedges' g:-0.521; 95% confidence interval,-0.956 to-0.085; P =.019). Wide area injection including the fundus or body rather than the antrum only was associated with weight loss. Multiple injections (>10) were associated with weight loss. However, a large amount of botulinum toxin A (500 IU) was not associated with weight loss. Sensitivity analyses showed consistent results. Meta-regression for the botulinum toxin A dose and number of injections showed consistent results. Publication bias was not detected. Conclusion In this analysis, intragastric injection of botulinum toxin A is effective for the treatment of obesity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.title | Effect of intragastric injection of botulinum toxin A for the treatment of obesity: a meta-analysis and meta-regression. | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Jai Hoon | - |
dc.identifier.doi | 10.1016/j.gie.2014.12.025 | - |
dc.identifier.scopusid | 2-s2.0-84927575432 | - |
dc.identifier.wosid | 000352706600007 | - |
dc.identifier.bibliographicCitation | GASTROINTESTINAL ENDOSCOPY , v.81, no.5, pp.1141 - 1149.e7 | - |
dc.relation.isPartOf | GASTROINTESTINAL ENDOSCOPY | - |
dc.citation.title | GASTROINTESTINAL ENDOSCOPY | - |
dc.citation.volume | 81 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1141 | - |
dc.citation.endPage | 1149.e7 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | WEIGHT-REDUCTION | - |
dc.subject.keywordPlus | PUBLICATION BIAS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0016510714025954?via%3Dihub | - |
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