Effect of intragastric injection of botulinum toxin A for the treatment of obesity: a meta-analysis and meta-regression.
- Authors
- Bang, Chang Seok; Baik, Gwang Ho; Shin, In Soo; Kim, Jin Bong; Suk, Ki Tae; Yoon, Jai Hoon; Kim, Yeon Soo; Kim, Dong Joon
- Issue Date
- May-2015
- Publisher
- MOSBY-ELSEVIER
- Citation
- GASTROINTESTINAL ENDOSCOPY , v.81, no.5, pp.1141 - 1149.e7
- Indexed
- SCIE
SCOPUS
- Journal Title
- GASTROINTESTINAL ENDOSCOPY
- Volume
- 81
- Number
- 5
- Start Page
- 1141
- End Page
- 1149.e7
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157214
- DOI
- 10.1016/j.gie.2014.12.025
- ISSN
- 0016-5107
- Abstract
- Background Controversies persist regarding the effect of intragastric injection of botulinum toxin A for the treatment of obesity. Objective To assess the efficacy of intragastric botulinum toxin injection for the treatment of obesity. Design A systematic literature review was conducted by using the core databases. Pre-and posttreatment body weight data were extracted and analyzed by using Hedges' g. A random-effects model was applied. The methodological quality of the enrolled studies was assessed by the risk of bias table and Newcastle-Ottawa Scale. Publication bias was evaluated via the funnel plot, trim and fill method, Egger's test, and rank correlation test. Setting Meta-analysis of 8 studies. Patients A total of 115 patients (79 treated vs 36 placebo). Intervention Intragastric botulinum toxin A injection. Main Outcome Measurements Hedges' g, calculated from pre-and posttreatment body weight data and comparison of body weight changes between treatment and placebo group. Results The treatment group was associated with weight loss in a pre/post comparative approach and compared with the placebo group (Hedges' g:-0.443; 95% confidence interval,-0.845 to-0.040; P =.031; and Hedges' g:-0.521; 95% confidence interval,-0.956 to-0.085; P =.019). Wide area injection including the fundus or body rather than the antrum only was associated with weight loss. Multiple injections (>10) were associated with weight loss. However, a large amount of botulinum toxin A (500 IU) was not associated with weight loss. Sensitivity analyses showed consistent results. Meta-regression for the botulinum toxin A dose and number of injections showed consistent results. Publication bias was not detected. Conclusion In this analysis, intragastric injection of botulinum toxin A is effective for the treatment of obesity.
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