Sorghum extract exerts cholesterol-lowering effects through the regulation of hepatic cholesterol metabolism in hypercholesterolemic mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Eunyoung | - |
dc.contributor.author | Kim, Sehee | - |
dc.contributor.author | Park, Yongsoon | - |
dc.date.accessioned | 2022-07-15T22:59:18Z | - |
dc.date.available | 2022-07-15T22:59:18Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0963-7486 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157319 | - |
dc.description.abstract | The purpose of this study is to investigate that sorghum extract (SE) exerts cholesterol-lowering effects through the regulation of hepatic cholesterol metabolism-related protein expression. C57BL/6 mice were fed a modified AIN-93G diet (NC) with saline, or a modified AIN-93G diet with 2% cholesterol and 0.25% cholic acid with either saline (HC) or 600 mg SE/kg body weight (HC-SE). Levels of total cholesterol and triglycerides in serum and liver were significantly lower in HC-SE than in HC. The expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase, sterol regulatory elementary binding protein2 and fatty acid synthase were significantly lower, whereas phosphorylated AMP-activated protein kinase expression was significantly higher in HC-SE than in HC. Cholesterol 7-alpha hydroxylase expression was also significantly higher in mice given SE than in those given HC. These results suggest that the cholesterol-lowering effect of SE may be related to the regulation of hepatic cholesterol metabolism in this mouse model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Sorghum extract exerts cholesterol-lowering effects through the regulation of hepatic cholesterol metabolism in hypercholesterolemic mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.3109/09637486.2014.1000839 | - |
dc.identifier.scopusid | 2-s2.0-84929875069 | - |
dc.identifier.wosid | 000354952000011 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, v.66, no.3, pp.308 - 313 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | - |
dc.citation.title | INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | - |
dc.citation.volume | 66 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 308 | - |
dc.citation.endPage | 313 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | HMG-COA REDUCTASE | - |
dc.subject.keywordPlus | STEROL 12-ALPHA-HYDROXYLASE | - |
dc.subject.keywordPlus | SERUM-CHOLESTEROL | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | LDL RECEPTOR | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordAuthor | Hepatic protein expression | - |
dc.subject.keywordAuthor | high cholesterol | - |
dc.subject.keywordAuthor | mice | - |
dc.subject.keywordAuthor | sorghum | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/09637486.2014.1000839 | - |
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