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Spheroform: Therapeutic Spheroid-Forming Nanotextured Surfaces Inspired by Desert Beetle Physosterna cribripes

Authors
Lee, MihyunYang, KisukHwang, Yong HwaByun, YoungroLee, Dong YunCho, Seung-WooLee, Haeshin
Issue Date
Mar-2015
Publisher
WILEY
Keywords
desert beetles; islet cells; mesenchymal stem cells; polydopamine; therapeutic spheroids
Citation
ADVANCED HEALTHCARE MATERIALS, v.4, no.4, pp.511 - 515
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED HEALTHCARE MATERIALS
Volume
4
Number
4
Start Page
511
End Page
515
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157805
DOI
10.1002/adhm.201400429
ISSN
2192-2640
Abstract
An approach is presented to create arrays of quasi-spherical microdroplets by surfaces called "spheroform" inspired by micro-/nanostructures found in the back of the Namib desert beetle. Spheroform is fabricated by microarray formation of catecholamine polymers on the superhydrophobic background. Spheroform is able to precisely control spheroid sizes of therapeutic islet cells and mesenchymal stem cells. The therapeutic spheroids exhibit improved biochemical activities.
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