Reappraisal of serum alpha‐foetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment
DC Field | Value | Language |
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dc.contributor.author | Kim, Gi-Ae | - |
dc.contributor.author | Seock, Chang Hyeon | - |
dc.contributor.author | Park, Jang Won | - |
dc.contributor.author | An, Ji hyun | - |
dc.contributor.author | Lee, Kwang-Sun | - |
dc.contributor.author | Yang, Jee Eun | - |
dc.contributor.author | Lim, Young-Suk | - |
dc.contributor.author | Kim, Kang Mo | - |
dc.contributor.author | Shim, Ju Hyun | - |
dc.contributor.author | Lee, Danbi | - |
dc.contributor.author | Lee, Han Chu | - |
dc.date.accessioned | 2022-07-16T00:50:58Z | - |
dc.date.available | 2022-07-16T00:50:58Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158051 | - |
dc.description.abstract | Background & Aims: The aim of this study was to re-evaluate the diagnostic performance of alpha-foetoprotein (AFP) as a surveillance test for hepatocellular carcinoma (HCC) in patients with hepatitis B virus-related chronic liver disease who were treated with entecavir (ETV). Methods: Between January 2007 and August 2012, we analysed 373 treatment-naïve patients with HBV-related chronic hepatitis (n = 229) or cirrhosis (n = 144) who were candidates for surveillance test, and were treated with ETV (0.5 mg/day) for longer than 12 months. To minimize the effect of AFP elevation caused by hepatitis activity, serum AFP levels were measured 12 months after the initiation of ETV treatment. Results: Hepatocellular carcinoma developed in 28 patients (7.5%) during a median follow-up period of 48.0 months (IQR = 40.5-57.3 months). The area under the receiver operating characteristic curve for AFP was 0.71 (95% CI = 0.59-0.84). The optimal AFP cut-off value was 13 ng/ml, leading to a sensitivity of 50.0%, specificity of 98.8%, positive predictive value of 77.8% and negative predictive value of 96.1%. In multivariate Cox analysis, an older age, the presence of cirrhosis and AFP levels of ≥20 ng/ml at 12 months after treatment were found to be significantly associated with an increased incidence of HCC. Conclusions: The role of serum AFP as a surveillance test should be re-evaluated in patients with HBV-related chronic liver diseases who were treated with antiviral therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Reappraisal of serum alpha‐foetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Ji hyun | - |
dc.identifier.doi | 10.1111/liv.12516 | - |
dc.identifier.scopusid | 2-s2.0-84921030842 | - |
dc.identifier.wosid | 000347723300030 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, v.35, no.1, pp.232 - 239 | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.citation.title | LIVER INTERNATIONAL | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 232 | - |
dc.citation.endPage | 239 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | CHRONIC HEPATITIS-B | - |
dc.subject.keywordPlus | CIRRHOTIC-PATIENTS | - |
dc.subject.keywordPlus | LIVER-TRANSPLANTATION | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordAuthor | alpha-foetoprotein | - |
dc.subject.keywordAuthor | entecavir | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/liv.12516 | - |
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