Reappraisal of serum alpha‐foetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment
- Authors
- Kim, Gi-Ae; Seock, Chang Hyeon; Park, Jang Won; An, Ji hyun; Lee, Kwang-Sun; Yang, Jee Eun; Lim, Young-Suk; Kim, Kang Mo; Shim, Ju Hyun; Lee, Danbi; Lee, Han Chu
- Issue Date
- Jan-2015
- Publisher
- WILEY-BLACKWELL
- Keywords
- alpha-foetoprotein; entecavir; hepatocellular carcinoma
- Citation
- LIVER INTERNATIONAL, v.35, no.1, pp.232 - 239
- Indexed
- SCIE
SCOPUS
- Journal Title
- LIVER INTERNATIONAL
- Volume
- 35
- Number
- 1
- Start Page
- 232
- End Page
- 239
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158051
- DOI
- 10.1111/liv.12516
- ISSN
- 1478-3223
- Abstract
- Background & Aims: The aim of this study was to re-evaluate the diagnostic performance of alpha-foetoprotein (AFP) as a surveillance test for hepatocellular carcinoma (HCC) in patients with hepatitis B virus-related chronic liver disease who were treated with entecavir (ETV). Methods: Between January 2007 and August 2012, we analysed 373 treatment-naïve patients with HBV-related chronic hepatitis (n = 229) or cirrhosis (n = 144) who were candidates for surveillance test, and were treated with ETV (0.5 mg/day) for longer than 12 months. To minimize the effect of AFP elevation caused by hepatitis activity, serum AFP levels were measured 12 months after the initiation of ETV treatment. Results: Hepatocellular carcinoma developed in 28 patients (7.5%) during a median follow-up period of 48.0 months (IQR = 40.5-57.3 months). The area under the receiver operating characteristic curve for AFP was 0.71 (95% CI = 0.59-0.84). The optimal AFP cut-off value was 13 ng/ml, leading to a sensitivity of 50.0%, specificity of 98.8%, positive predictive value of 77.8% and negative predictive value of 96.1%. In multivariate Cox analysis, an older age, the presence of cirrhosis and AFP levels of ≥20 ng/ml at 12 months after treatment were found to be significantly associated with an increased incidence of HCC. Conclusions: The role of serum AFP as a surveillance test should be re-evaluated in patients with HBV-related chronic liver diseases who were treated with antiviral therapy.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158051)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.