Impact of adjuvant chemotherapy in patients with upper tract urothelial carcinoma and lymphovascular invasion after radical nephroureterectomyopen access
- Authors
- Lee, Kwang Suk; Kim, Kwang Hyun; Yoon, YOUNG EUN; Choi, Kyung Hwa; Yang, Seung Choul; Han, Woong Kyu
- Issue Date
- Jan-2015
- Publisher
- Korean Urological Association
- Keywords
- Adjuvant chemotherapy; Kidney pelvis; Transitional cell carcinoma; Ureter; Urinary tract
- Citation
- Korean Journal of Urology, v.56, no.1, pp.41 - 47
- Indexed
- SCIE
SCOPUS
- Journal Title
- Korean Journal of Urology
- Volume
- 56
- Number
- 1
- Start Page
- 41
- End Page
- 47
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158055
- DOI
- 10.4111/kju.2015.56.1.41
- ISSN
- 20056737
- Abstract
- Purpose: To evaluate the impact of adjuvant chemotherapy (AC) in patients with upper tract urothelial carcinoma and lymphovascular invasion (LVI) after radical nephroureterectomy (RNU).
Materials and Methods: We retrospectively analyzed the clinical records and clinicopatholgic outcomes of patients (n=552) treated with RNU between 1986 and 2013. Patients treated with neoadjuvant chemotherapy and those for whom LVI status was not recorded were excluded. Patients were divided into two groups according to LVI (n=86) or no LVI (n=256).
Results: The study included 344 patients (240 men and 104 women) with a median of 53.9 months of follow-up (range, 1-297 months) after RNU. Tumors were organ confined (T2/N0) in 211 (61.3%) and tumor grade high in 291 (84.6%). AC was administered in 64 patients (18.6%). A total of 280 patients (81.4%) were treated with surgery alone. Patients with LVI tended to be older (p=0.049), have a higher pT stage (pT3/T4, p<0.001), be pN+ (p<0.001), have a high tumor grade (p<0.001), and experience recurrence (p<0.001). In the multivariate analysis, LVI was an independent prognostic factor for cancer-specific survival and overall survival (p=0.002 and p<0.001, respectively). The multivariate analysis demonstrated that in the subgroup of patients with LVI, AC was a significant prognostic factor for cancer-specific survival and overall survival (hazard ratio, 0.51; p=0.027 and hazard ratio, 0.50; p=0.025, respectively).
Conclusions: AC does not seem to reduce mortality in patients with advanced upper tract urothelial carcinoma after RNU. In the subgroup of patients with LVI, AC had a positive impact on cancer-specific survival and overall survival. LVI would be helpful for selecting patients who are appropriate for AC.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 비뇨의학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158055)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.