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Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
- Authors
- Hwang, Joo-Yeon; Sim, Xueling; Wu, Ying; Liang, Jun; Tabara, Yasuharu; Hu, Cheng; Hara, Kazuo; Tam, Claudia H. T.; Cai, Qiuyin; Zhao, Qi; Jee, Sunha; Takeuchi, Fumihiko; Go, Min Jin; Ong, Rick Twee Hee; Ohkubo, Takayoshi; Kim, Young Jin; Zhang, Rong; Yamauchi, Toshimasa; So, Wing Yee; Long, Jirong; Gu, Dongfeng; Lee, Nanette R.; Kim, Soriul; Katsuya, Tomohiro; Oh, Ji Hee; Liu, Jianjun; Umemura, Satoshi; Kim, Yeon-Jung; Jiang, Feng; Maeda, Shiro; Chan, Juliana C. N.; Lu, Wei; Hixson, James E.; Adair, Linda S.; Jung, Keum Ji; Nabika, Toru; Bae, Jae-Bum; Lee, Mi Hee; Seielstad, Mark; Young, Terri L.; Teo, Yik Ying; Kita, Yoshikuni; Takashima, Naoyuki; Osawa, Haruhiko; Lee, So-Hyun; Shin, Min-Ho; Shin, Dong Hoon; Choi, Bo Youl; Shi, Jiajun; Gao, Yu-Tang; Xiang, Yong-Bing; Zheng, Wei; Kato, Norihiro; Yoon, Miwuk; He, Jiang; Shu, Xiao Ou; Ma, Ronald C. W.; Kadowaki, Takashi; Jia, Weiping; Miki, Tetsuro; Qi, Lu; Tai, E. Shyong; Mohlke, Karen L.; Han, Bok-Ghee; Cho, Yoon Shin; Kim, Bong-Jo
- Issue Date
- Jan-2015
- Publisher
- American Diabetes Association
- Citation
- Diabetes, v.64, no.1, pp 291 - 298
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Diabetes
- Volume
- 64
- Number
- 1
- Start Page
- 291
- End Page
- 298
- ISSN
- 0012-1797
1939-327X
- Abstract
- Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
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