The influence of mild hypothermia on reversal of rocuronium-induced deep neuromuscular block with sugammadexopen access
- Authors
- Lee, Hee Jong; Kim, Kyo Sang; Jeong, Ji Seon; Kim, Kyu Nam; Lee, Byeong Chan
- Issue Date
- Jan-2015
- Publisher
- BMC
- Keywords
- Hypothermia; Neuromuscular blockade Rocuronium; Sugammadex
- Citation
- BMC ANESTHESIOLOGY, v.15, pp.1 - 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- BMC ANESTHESIOLOGY
- Volume
- 15
- Start Page
- 1
- End Page
- 6
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158181
- DOI
- 10.1186/1471-2253-15-7
- ISSN
- 1471-2253
- Abstract
- Background: Mild hypothermia may be frequently induced due to cool environments in the operating room. The study analyzed patient recovery time and response to sugammadex after a prolonged rocuronium-induced deep neuromuscular block (NMB) during mild hypothermia. Methods: Sixty patients were randomly (1: 1) allocated to the mild hypothermia and normothermia groups, defined as having core temperatures between 34.5 -35 degrees C and 36.5-37 degrees C, respectively. Patients received 0.6 mg/kg of rocuronium, followed by 7-10 mu g/kg/min to maintain a deep NMB [post-tetanic count (PTC) 1-2]. After surgery, the deep NMB was reversed with sugammadex 4.0 mg/kg. The primary end-point was the time until the train-of-four (TOF) ratio was 0.9. Results: The appropriate neuromuscular function (TOF ratio >= 0.9) was restored after sugammadex was administered, even after hypothermia. The length of recovery in the hypothermia patients [mean (SD), 171.1 (62.1) seconds (s)] was significantly slower compared with the normothermia patients [124.9 (59.2) s] (p = 0.005). There were no adverse effects from sugammadex. Conclusions: Sugammadex safely and securely reversed deep rocuronium-induced NMB during mild hypothermia. An additional 46 s was required for recovery from a deep NMB in hypothermia patients. Based on the results, we think this prolonged recovery time is clinically acceptable.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 마취통증의학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.