Supplementation of n-3 Polyunsaturated Fatty Acids for Major Depressive Disorder: A Randomized, Double-Blind, 12-Week, Placebo-Controlled Trial in Korea
DC Field | Value | Language |
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dc.contributor.author | Park, Yongsoon | - |
dc.contributor.author | Park, Yoo-Sin | - |
dc.contributor.author | Kim, Seok Hyeon | - |
dc.contributor.author | Oh, Dong Hoon | - |
dc.contributor.author | Park, Yong-Chon | - |
dc.date.accessioned | 2022-07-16T01:14:02Z | - |
dc.date.available | 2022-07-16T01:14:02Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0250-6807 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158301 | - |
dc.description.abstract | Background: Controversy over the efficacy of n-3 polyunsaturated fatty acids (PUFAs) in depression continues to this day. The present study investigated the hypothesis that n-3 PUFA supplementation reduces depressive symptoms in Korean patients with major depressive disorder. Methods: In a randomized, double-blind, placebo-controlled, 12-week, parallel-group trial, 35 patients with Center for Epidemiological Studies Depression Scale Korean version (CES-D-K) scores >= 25 and depression confirmed by a psychiatrist were assigned to take either 3 capsules of n-3 PUFAs (1,140 mg of EPA + 600 mg of DHA; n = 18) or placebo (olive oil + safflower oil; n = 17). Results: Supplementation with n-3 PUFAs significantly reduced Clinical Global Impression Improvement (CGI-I) scores as compared with intake of placebo using intention-to-treat analysis with last-observation-carried-forward after adjusting for energy, fat, and fish intake. However, the CES-D-K, Hamilton Depression Rating Scale-17, and Clinical Global Impression Scale scores did not significantly differ between the n-3 PUFA and placebo groups. After supplementation with n-3 PUFAs, the erythrocyte levels of n-3 PUFAs were significantly increased, but n-6 PUFA levels were decreased. Conclusions: n-3 PUFAs demonstrated an advantage over placebo that did not reach clinical significance, although CGI-I score was significantly decreased in the n-3 PUFA group as compared with the placebo group. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.title | Supplementation of n-3 Polyunsaturated Fatty Acids for Major Depressive Disorder: A Randomized, Double-Blind, 12-Week, Placebo-Controlled Trial in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.contributor.affiliatedAuthor | Kim, Seok Hyeon | - |
dc.contributor.affiliatedAuthor | Park, Yong-Chon | - |
dc.identifier.doi | 10.1159/000377640 | - |
dc.identifier.scopusid | 2-s2.0-84933034276 | - |
dc.identifier.wosid | 000356487500013 | - |
dc.identifier.bibliographicCitation | ANNALS OF NUTRITION AND METABOLISM, v.66, no.2-3, pp.141 - 148 | - |
dc.relation.isPartOf | ANNALS OF NUTRITION AND METABOLISM | - |
dc.citation.title | ANNALS OF NUTRITION AND METABOLISM | - |
dc.citation.volume | 66 | - |
dc.citation.number | 2-3 | - |
dc.citation.startPage | 141 | - |
dc.citation.endPage | 148 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | FISH CONSUMPTION | - |
dc.subject.keywordPlus | ETHYL-EICOSAPENTAENOATE | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | OIL | - |
dc.subject.keywordAuthor | Korean | - |
dc.subject.keywordAuthor | Major depressive disorder | - |
dc.subject.keywordAuthor | n-3 polyunsaturated fatty acid | - |
dc.subject.keywordAuthor | Randomized placebo-controlled trial | - |
dc.identifier.url | https://www.karger.com/Article/FullText/377640 | - |
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