FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Qi, Qibin | - |
dc.contributor.author | Kilpelainen, Tuomas O. | - |
dc.contributor.author | Downer, Mary K. | - |
dc.contributor.author | Tanaka, Toshiko | - |
dc.contributor.author | Smith, Caren E. | - |
dc.contributor.author | Sluijs, Ivonne | - |
dc.contributor.author | Sonestedtl, Emily | - |
dc.contributor.author | Chull, Audrey Y. | - |
dc.contributor.author | Renstrom, Frida | - |
dc.contributor.author | Lin, Xiaochen | - |
dc.contributor.author | Angquist, Lars H. | - |
dc.contributor.author | Huang, Jinyan | - |
dc.contributor.author | Liu, Zhonghua | - |
dc.contributor.author | Li, Yanping | - |
dc.contributor.author | Ali, Muhammad Asif | - |
dc.contributor.author | Xu, Min | - |
dc.contributor.author | Ahluwalia, Tarunveer Singh | - |
dc.contributor.author | Boer, Jolanda M. A. | - |
dc.contributor.author | Chen, Peng | - |
dc.contributor.author | Daimon, Makoto | - |
dc.contributor.author | Eriksson, Johan | - |
dc.contributor.author | Perola, Markus | - |
dc.contributor.author | Friedlander, Yechiel | - |
dc.contributor.author | Gao, Yu-Tang | - |
dc.contributor.author | Heppe, Denise H. M. | - |
dc.contributor.author | Holloway, John W. | - |
dc.contributor.author | Houston, Denise K. | - |
dc.contributor.author | Kanoni, Stavroula | - |
dc.contributor.author | Kim, Yu-Mi | - |
dc.contributor.author | Laaksonen, Maarit A. | - |
dc.contributor.author | Jaaskelainen, Tiina | - |
dc.contributor.author | Lee, Nanette R. | - |
dc.contributor.author | Lehtimaki, Terho | - |
dc.contributor.author | Lemaitre, Rozenn N. | - |
dc.contributor.author | Lu, Wei | - |
dc.contributor.author | Luben, Robert N. | - |
dc.contributor.author | Manichaiku, Ani | - |
dc.contributor.author | Mannisto, Satu | - |
dc.contributor.author | Marques-Vidal, Pedro | - |
dc.contributor.author | Monda, Keri L. | - |
dc.contributor.author | Ngwa, Julius S. | - |
dc.contributor.author | Perusse, Louis | - |
dc.contributor.author | van Rooij, Frank J. A. | - |
dc.contributor.author | Xiang, Yong-Bing | - |
dc.contributor.author | Wen, Wanqing | - |
dc.contributor.author | Wojczynski, Mary K. | - |
dc.contributor.author | Zhu, Jingwen | - |
dc.contributor.author | Borecki, Ingrid B. | - |
dc.contributor.author | Bouchard, Claude | - |
dc.contributor.author | Cai, Qiuyin | - |
dc.contributor.author | Cooper, Cyrus | - |
dc.contributor.author | Dedoussis, George V. | - |
dc.contributor.author | Deloukas, Panos | - |
dc.contributor.author | Ferrucci, Luigi | - |
dc.contributor.author | Forouhi, Nita G. | - |
dc.contributor.author | Hansen, Torben | - |
dc.contributor.author | Christiansen, Lene | - |
dc.contributor.author | Hofman, Albert | - |
dc.contributor.author | Johansson, Ingegerd | - |
dc.contributor.author | Jorgensen, Torben | - |
dc.contributor.author | Karasawa, Shigeru | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Kim, Mi-Kyung | - |
dc.contributor.author | Kristiansson, Kati | - |
dc.contributor.author | Li, Huaixing | - |
dc.contributor.author | Lin, Xu | - |
dc.contributor.author | Liu, Yongmei | - |
dc.contributor.author | Lohman, Kurt K. | - |
dc.contributor.author | Long, Jirong | - |
dc.contributor.author | Mikkila, Vera | - |
dc.contributor.author | Mozaffarian, Dariush | - |
dc.contributor.author | North, Kari | - |
dc.contributor.author | Pedersen, Oluf | - |
dc.contributor.author | Raitakari, Olli | - |
dc.contributor.author | Rissanen, Harri | - |
dc.contributor.author | Tuomilehto, Jaakko | - |
dc.contributor.author | van der Schouw, Yvonne T. | - |
dc.contributor.author | Uitterlinden, Andre G. | - |
dc.contributor.author | Zillikens, M. Carola | - |
dc.contributor.author | Franco, Oscar H. | - |
dc.contributor.author | Tai, E. Shyong | - |
dc.contributor.author | Shu, Xiao Ou | - |
dc.contributor.author | Siscovick, David S. | - |
dc.contributor.author | Toft, Ulla | - |
dc.contributor.author | Verschuren, W. M. Monique | - |
dc.contributor.author | Vollenweider, Peter | - |
dc.contributor.author | Wareham, Nicholas J. | - |
dc.contributor.author | Witteman, Jacqueline C. M. | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Ridker, Paul M. | - |
dc.contributor.author | Kang, Jae H. | - |
dc.contributor.author | Liang, Liming | - |
dc.contributor.author | Jensen, Majken K. | - |
dc.contributor.author | Curhan, Gary C. | - |
dc.contributor.author | Pasquale, Louis R. | - |
dc.contributor.author | Hunter, David J. | - |
dc.contributor.author | Mohlke, Karen L. | - |
dc.contributor.author | Uusitupa, Matti | - |
dc.contributor.author | Cupples, L. Adrienne | - |
dc.contributor.author | Rankinen, Tuomo | - |
dc.contributor.author | Orho-Melander, Marju | - |
dc.contributor.author | Wang, Tao | - |
dc.contributor.author | Chasman, Daniel I. | - |
dc.contributor.author | Franks, Paul W. | - |
dc.contributor.author | Sorensen, Thorkild I. A. | - |
dc.contributor.author | Hu, Frank B. | - |
dc.contributor.author | Loos, Ruth J. F. | - |
dc.contributor.author | Nettleton, Jennifer A. | - |
dc.contributor.author | Qi, Lu | - |
dc.date.accessioned | 2022-07-16T01:44:58Z | - |
dc.date.available | 2022-07-16T01:44:58Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 0964-6906 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158512 | - |
dc.description.abstract | FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BM I. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 x 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 x 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 x 10(-16)), and relative weak associations with lower total energy intake (-6.4 [- 10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [- 0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 x 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yu-Mi | - |
dc.contributor.affiliatedAuthor | Kim, Mi-Kyung | - |
dc.identifier.doi | 10.1093/hmg/ddu411 | - |
dc.identifier.scopusid | 2-s2.0-84914107948 | - |
dc.identifier.wosid | 000347923000023 | - |
dc.identifier.bibliographicCitation | HUMAN MOLECULAR GENETICS, v.23, no.25, pp.6961 - 6972 | - |
dc.relation.isPartOf | HUMAN MOLECULAR GENETICS | - |
dc.citation.title | HUMAN MOLECULAR GENETICS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 25 | - |
dc.citation.startPage | 6961 | - |
dc.citation.endPage | 6972 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | OBESITY-ASSOCIATED GENE | - |
dc.subject.keywordPlus | FAT MASS | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | ENERGY-INTAKE | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | METABOLIC-RATE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | RS9939609 | - |
dc.subject.keywordPlus | GENOTYPE | - |
dc.subject.keywordPlus | RISK | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.