Randomized controlled trial of sodium phosphate tablets vs polyethylene glycol solution for colonoscopy bowel cleansing
- Authors
- Jung, Yoon Suk; Lee, Chang Kyun; Kim, Hyo Jong; Eun, Chang Soo; Han, Dong Soo; Park, Dong Il
- Issue Date
- Nov-2014
- Publisher
- BAISHIDENG PUBLISHING GROUP INC
- Keywords
- Sodium phosphate tablets; Polyethylene glycol; Colonoscopy; Bowel preparation
- Citation
- WORLD JOURNAL OF GASTROENTEROLOGY, v.20, no.42, pp.15845 - 15851
- Indexed
- SCIE
SCOPUS
- Journal Title
- WORLD JOURNAL OF GASTROENTEROLOGY
- Volume
- 20
- Number
- 42
- Start Page
- 15845
- End Page
- 15851
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158783
- DOI
- 10.3748/wjg.v20.i42.15845
- ISSN
- 1007-9327
- Abstract
- AIM: To compare efficacy, patient compliance, acceptability, satisfaction, safety, and adenoma detection rate of sodium phosphate tablets (NaP, CLICOLONTM) to a standard 4 L polyethylene glycol (PEG) solution for bowel cleansing for adults undergoing colonoscopy. METHODS: In this multicenter, randomized, prospective, investigator-blind study, the relatively young (19-60 years) healthy outpatients without comorbidity were randomly assigned to one of two arms. All colonoscopy were scheduled in the morning. The NaP group was asked to take 4 tablets, 5 times the evening before and 4 tablets, 3 times early on the morning of the colonos-copy. The PEG group was asked to ingest 2 L of solution the evening before and 2 L early in the morning of the procedure. Adequacy of bowel preparation was scored using the Boston bowel preparation scale. RESULTS: No significant differences were observed between the NaP group (n = 158) and PEG group (n = 162) in bowel cleansing quality (adequate preparation 93.0% vs 92.6%, p = 0.877), patient compliance (p = 0.228), overall adverse events (63.3% vs 69.1%, p = 0.269), or adenoma detection rate (34.8% vs 35.2%, p = 0.944). Patient acceptability, satisfaction, and patient rating of taste were higher in the NaP group than in the PEG group (p < 0.001). CONCLUSION: NaP tablets, compared with PEG solution, produced equivalent colon cleansing, did not cause more side effects, and had better patient acceptability and satisfaction in the relatively young (age < 60 years) healthy individuals without comorbidity. An oral tablet formulation could make bowel preparation less burdensome, resulting in greater patient participation in screening programs.
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