Impact of serial measurements of lysophosphatidylcholine on 28-day mortality prediction in patients admitted to the intensive care unit with severe sepsis or septic shock
- Authors
- Park, Dong Won; Kwak, Dong Shin; Park, Yun Young; Chang, Youjin; Huh, Jin Won; Lim, Chae-Man; Koh, Younsuck; Song, Dong-Keun; Hong, Sang-Bum
- Issue Date
- Oct-2014
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Keywords
- Lysophosphatidylcholine; Mortality; Severe sepsis; Septic shock; Intensive care unit
- Citation
- JOURNAL OF CRITICAL CARE, v.29, no.5, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CRITICAL CARE
- Volume
- 29
- Number
- 5
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158974
- DOI
- 10.1016/j.jcrc.2014.05.003
- ISSN
- 0883-9441
- Abstract
- Purpose: The purpose of this study is to investigate the effect of serial lysophosphatidylcholine (LPC) measurement on 28-day mortality prediction in patients with severe sepsis or septic shock admitted to the medical intensive care unit (ICU). Methods: This is a prospective observational study of 74 ICU patients in a tertiary hospital. Serum LPC, white blood cell, C-reactive protein, and procalcitonin (PCT) levels were measured at baseline (day 1 of enrollment) and day 7. The LPC concentrations were compared with inflammatory markers using their absolute levels and relative changes. Results: The LPC concentration on day 7 was significantly lower in nonsurvivors than in survivors (68.45 +/- 42.36 mu mol/L and 99.76 +/- 73.65 mu mol/L; P = .04). A decreased LPC concentration on day 7 to its baseline as well as a sustained high concentration of PCT on day 7 at more than 50% of its baseline value was useful for predicting the 28-day mortality. Prognostic utility was substantially improved when combined LPC and PCT criteria were applied to 28-day mortality outcome predictions. Furthermore, LPC concentrations increased over time in patients with appropriate antibiotics but not in those with inappropriate antibiotics. Conclusions: Serial measurements of LPC help in the prediction of 28-day mortality in ICU patients with severe sepsis or septic shock.
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