Retinal Nerve Fiber Layer Volume Measurements in Healthy Subjects Using Spectral Domain Optical Coherence Tomography
- Authors
- Shin, Joong Won; Uhm, Ki Bang; Seong, Mincheol; Lee, Dong Eik
- Issue Date
- Oct-2014
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- retinal nerve fiber layer; volume; spectral domain optical coherence tomography
- Citation
- JOURNAL OF GLAUCOMA, v.23, no.8, pp.567 - 573
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GLAUCOMA
- Volume
- 23
- Number
- 8
- Start Page
- 567
- End Page
- 573
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159047
- DOI
- 10.1097/IJG.0b013e3182948673
- ISSN
- 1057-0829
- Abstract
- Purpose: To report retinal nerve fiber layer (RNFL) volume measurement using spectral domain optical coherence tomography (SD-OCT). We determined the characteristics and effecting factors of the RNFL volume in healthy eyes. Methods: Eighty-six eyes from 86 healthy volunteers were included. All participants underwent 3D-disc scanning using SD-OCT. We developed a computer program using Matlab software to extract RNFL thickness values from colored topographic RNFL thickness map. Total average, quadrant, and clock-hour RNFL volume were automatically calculated between 2.5 and 5 mm diameter circles using the length, width, and height of each pixel derived from the RNFL thickness map. Results: The mean total RNFL volume was 1.478 +/- 0.124 mm(3) and RNFL volume profiles showed double-hump patterns. RNFL volumes of superior and inferior quadrants were significantly greater than those of temporal and nasal quadrants (all P < 0.001). A strong correlation existed between RNFL volume and conventional circumpapillary RNFL thickness measured by built-in software (R = 0.895 to 0.972). Image quality and age were associated with RNFL volume measurement. Conclusions: RNFL volume measurement from RNFL thickness map analysis provides an alternative approach to characterizing and evaluating RNFL. RNFL volume measurement may be valuable for the objective and quantitative evaluation of 3-dimensional RFNL changes.
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