Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance
DC Field | Value | Language |
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dc.contributor.author | Nam, Ho Hyun | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Jeon, Hye Joon | - |
dc.contributor.author | Lee, Jai Sun | - |
dc.contributor.author | Saeed, Waqar Khalid | - |
dc.contributor.author | Kim, Eun Kyung | - |
dc.date.accessioned | 2022-07-16T03:11:49Z | - |
dc.date.available | 2022-07-16T03:11:49Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159247 | - |
dc.description.abstract | AIM: To evaluate the effects of osthol on intrahepatic fat synthesis, beta-oxidation, inflammation, and insulin resistance by multifaceted analysis. METHODS: Sprague-Dawley rats (n = 30) were randomly divided into control, non-alcoholic fatty liver disease (NAFLD), and osthol groups. NAFLD and osthol groups were fed with a high-fat diet for 14 wk. After 8 wk of the high-fat diet, the osthol group also received osthol 20 mg/kg orally 5 times/wk. To assess the insulin resistance, oral glucose tolerance was performed at the end of 14 wk. Immunohistochemical (4-HNE, F4/80) and hematoxylin and eosin (HE) staining were performed on liver tissue extracts after animal sacrifice at 14 wk. SREBP1c, FAS, SCD-1, PPAR-alpha, CROT, MCP-1, IRS-1, and IRS-2 mRNA expressions were assessed with reverse transcription-polymerase chain reaction. RESULTS: HE staining revealed that, compared with the NAFLD group, the osthol group showed significantly decreased intrahepatic fat content (39.4% vs 21.0%; P = 0.021). SREBP1c expression in the NAFLD group increased compared to controls (P = 0.0001), while osthol treatment decreased SREBP1c expression compared with the NAFLD group (P = 0.0059). In the osthol group, intrahepatic FAS and SCD-1, which act downstream of SREBP1c, decreased significantly compared with the NAFLD group. Moreover, PPAR-alpha expression in the osthol group was also significantly higher than in the NAFLD group (P = 0.0147). CONCLUSION: Osthol treatment attenuated liver steatosis by decreasing de novo liver triglyceride synthesis and had nominal effects on insulin resistance and liver inflammation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.title | Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.identifier.doi | 10.3748/wjg.v20.i33.11753 | - |
dc.identifier.scopusid | 2-s2.0-84909608173 | - |
dc.identifier.wosid | 000341718600025 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.20, no.33, pp.11753 - 11761 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 20 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 11753 | - |
dc.citation.endPage | 11761 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | NONALCOHOLIC FATTY LIVER | - |
dc.subject.keywordPlus | VITAMIN-E | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | STEATOHEPATITIS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | ROSIGLITAZONE | - |
dc.subject.keywordPlus | IMPROVEMENT | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordAuthor | Osthol | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Sterol regulatory element binding protein | - |
dc.identifier.url | https://www.wjgnet.com/1007-9327/full/v20/i33/11753.htm | - |
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