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Cited 12 time in webofscience Cited 14 time in scopus
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Flexible elastomer patch with vertical silicon nanoneedles for intracellular and intratissue nanoinjection of biomoleculesopen access

Authors
Kim, HyungjunJang, HanminKim, BongjoongKim, Min KuWie, Dae SeungLee, Heung SooKim, Dong RipLee, Chi Hwan
Issue Date
Nov-2018
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Citation
SCIENCE ADVANCES, v.4, no.11, pp.1 - 8
Indexed
SCIE
SCOPUS
Journal Title
SCIENCE ADVANCES
Volume
4
Number
11
Start Page
1
End Page
8
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15950
DOI
10.1126/sciadv.aau6972
ISSN
2375-2548
Abstract
Vertically ordered arrays of silicon nanoneedles (Si NNs), due to their nanoscale dimension and low cytotoxicity, could enable minimally invasive nanoinjection of biomolecules into living biological systems such as cells and tissues. Although production of these Si NNs on a bulk Si wafer has been achieved through standard nanofabrication technology, there exists a large mismatch at the interface between the rigid, flat, and opaque Si wafer and soft, curvilinear, and optically transparent biological systems. Here, we report a unique methodology that is capable of constructing vertically ordered Si NNs on a thin layer of elastomer patch to flexibly and transparently interface with biological systems. The resulting outcome provides important capabilities to form a mechanically elastic interface between Si NNs and biological systems, and simultaneously enables direct imaging of their real-time inter-actions under the transparent condition. We demonstrate its utility in intracellular, intradermal, and intramuscular nanoinjection of biomolecules into various kinds of biological cells and tissues at their length scales.
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COLLEGE OF ENGINEERING (SCHOOL OF MECHANICAL ENGINEERING)
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