Hierarchical Silicon Nanospikes Membrane for Rapid and High-Throughput Mechanical Cell Lysisopen access
- Authors
- So, Hong yun; Lee, Kunwoo; Seo, Young Ho; Murthy, Niren; Pisano, Albert P.
- Issue Date
- May-2014
- Publisher
- AMER CHEMICAL SOC
- Keywords
- hierarchical structure; porous silicon membrane; ultrasharp nanospikes; electrochemical etching; cell lysis; point-of-care diagnostics
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.6, no.10, pp.6993 - 6997
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 6
- Number
- 10
- Start Page
- 6993
- End Page
- 6997
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159953
- DOI
- 10.1021/am501221b
- ISSN
- 1944-8244
- Abstract
- This letter reports an efficient and compatible silicon membrane combining the physical properties of nanospikes and microchannel arrays for mechanical cell lysis. This hierarchical silicon nanospikes membrane was created to mechanically disrupt cells for a rapid process with high throughput, and it can be assembled with commercial syringe filter holders. The membrane was fabricated by photoelectrochemical overetching to form ultrasharp nanospikes in situ along the edges of the microchannel arrays. The intracellular protein and nucleic acid concentrations obtained using the proposed membrane within a short period of time were quantitatively higher than those obtained by routine, conventional acoustic and chemical lysis methods.
- Files in This Item
-
- Appears in
Collections - 서울 공과대학 > 서울 기계공학부 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159953)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.