Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Kim, So Ri | - |
dc.contributor.author | Oh, Youngman | - |
dc.contributor.author | Cho, Seong Ho | - |
dc.contributor.author | Schleimer, Robe | - |
dc.contributor.author | Lee, Yong Chul) | - |
dc.date.accessioned | 2022-07-16T05:13:10Z | - |
dc.date.available | 2022-07-16T05:13:10Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 1044-1549 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160165 | - |
dc.description.abstract | Insulin-like growth factor (IGF)-I has been recognized to play critical roles in the pathogenesis of asthma, whereas IGF-binding protein (IGFBP)-3 blocks crucial physiologic manifestations of asthma. IGF-I enhances subepithelial fibrosis, airway inflammation, airway hyperresponsiveness, and airway smooth muscle hyperplasia by interacting with various inflammatory mediators and complex signaling pathways, such as intercellular adhesion molecule-1, and the hypoxia-inducible factor/vascular endothelial growth factor axis. On the other hand, IGFBP-3 decreases airway inflammation and airway hyperresponsiveness through IGFBP-3 receptor-mediated activation of caspases, which subsequently inhibits NF-κB signaling pathway. It also inhibits the IGF-I/hypoxia-inducible factor/vascular endothelial growth factor axis via IGF-I-dependent and/or IGF-I-independent mechanisms. This Translational Review summarizes the role of IGF-I and IGFBP-3 in the context of allergic airway disease, and discusses the therapeutic potential of various strategies targeting the IGF-I and IGFBP-3 signaling pathways for the management of asthma. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER THORACIC SOC | - |
dc.title | Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun | - |
dc.identifier.doi | 10.1165/rcmb.2013-0397TR | - |
dc.identifier.scopusid | 2-s2.0-84898755074 | - |
dc.identifier.wosid | 000334403900001 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, v.50, no.4, pp.667 - 677 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | - |
dc.citation.title | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | - |
dc.citation.volume | 50 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 667 | - |
dc.citation.endPage | 677 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기 학술지(Review) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | AIRWAY SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | ACID-LABILE SUBUNIT | - |
dc.subject.keywordPlus | FACTOR (IGF)-BINDING PROTEIN-3 | - |
dc.subject.keywordPlus | REGULATES IL-17 EXPRESSION | - |
dc.subject.keywordPlus | AMINO-TERMINAL FRAGMENT | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | IGF-BINDING | - |
dc.subject.keywordPlus | FACTOR BINDING-PROTEIN-3 | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordAuthor | insulin-like growth factor-I | - |
dc.subject.keywordAuthor | insulin-like growth factor-binding protein-3 | - |
dc.subject.keywordAuthor | asthma | - |
dc.identifier.url | https://www.atsjournals.org/doi/full/10.1165/rcmb.2013-0397TR | - |
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