Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma
- Authors
- Lee, Hyun; Kim, So Ri; Oh, Youngman; Cho, Seong Ho; Schleimer, Robe; Lee, Yong Chul)
- Issue Date
- Apr-2014
- Publisher
- AMER THORACIC SOC
- Keywords
- insulin-like growth factor-I; insulin-like growth factor-binding protein-3; asthma
- Citation
- AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, v.50, no.4, pp.667 - 677
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Volume
- 50
- Number
- 4
- Start Page
- 667
- End Page
- 677
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160165
- DOI
- 10.1165/rcmb.2013-0397TR
- ISSN
- 1044-1549
- Abstract
- Insulin-like growth factor (IGF)-I has been recognized to play critical roles in the pathogenesis of asthma, whereas IGF-binding protein (IGFBP)-3 blocks crucial physiologic manifestations of asthma. IGF-I enhances subepithelial fibrosis, airway inflammation, airway hyperresponsiveness, and airway smooth muscle hyperplasia by interacting with various inflammatory mediators and complex signaling pathways, such as intercellular adhesion molecule-1, and the hypoxia-inducible factor/vascular endothelial growth factor axis. On the other hand, IGFBP-3 decreases airway inflammation and airway hyperresponsiveness through IGFBP-3 receptor-mediated activation of caspases, which subsequently inhibits NF-κB signaling pathway. It also inhibits the IGF-I/hypoxia-inducible factor/vascular endothelial growth factor axis via IGF-I-dependent and/or IGF-I-independent mechanisms. This Translational Review summarizes the role of IGF-I and IGFBP-3 in the context of allergic airway disease, and discusses the therapeutic potential of various strategies targeting the IGF-I and IGFBP-3 signaling pathways for the management of asthma.
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