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Cross-linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model
- Authors
- Park, Ji Won; Ku, Sook Hee; Moon, Hyung-Ho; Lee, Minhyung; Choi, Donghoon; Yang, Jaemoon; Huh, Yong-Min; Jeong, Ji Hoon; Park, Tae Gwan; Mok, Hyejung; Kim, Sun Hwa
- Issue Date
- Mar-2014
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- cell engineering; cerebral ischemia model; cross-linked iron oxide nanoparticles; magnetic resonance imaging; mesenchymal stem cells
- Citation
- MACROMOLECULAR BIOSCIENCE, v.14, no.3, pp.380 - 389
- Indexed
- SCIE
SCOPUS
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 14
- Number
- 3
- Start Page
- 380
- End Page
- 389
- ISSN
- 1616-5187
- Abstract
- Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area.
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Collections - 서울 공과대학 > 서울 생명공학과 > 1. Journal Articles
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Related Researcher
- Lee, Min hyung
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)