Follow-up Testing of Interferon-Gamma Release Assays Are Useful in Ankylosing Spondylitis Patients Receiving Anti-Tumor Necrosis Factor Alpha for Latent Tuberculosis Infectionopen access
- Authors
- Son, Chang-Nam; Jun, Jae-Bum; Kim, Jong-Heon; Sung, Il-Hoon; Yoo, Dae-Hyun; Kim, Tae-Hwan
- Issue Date
- 2014
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Ankylosing Spondylitis; Interferon-Gamma Release Assay; Anti-Tumor Necrosis Factor; Latent Tuberculosis Infection
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.8, pp.1090 - 1093
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 29
- Number
- 8
- Start Page
- 1090
- End Page
- 1093
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161061
- DOI
- 10.3346/jkms.2014.29.8.1090
- ISSN
- 1011-8934
- Abstract
- We evaluated the utility of follow-up interferon-gamma release assays (IGRAs) for the diagnosis of reactivation of latent tuberculosis infection (LTBI) or new tuberculosis in ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor alpha (anti-TNF alpha). The study participants (n = 127) had a negative IGRA screening before receiving anti-TNF alpha and were evaluated by follow-up IGRA. We retrospectively examined data of the subjects according to age, gender, tuberculosis prophylaxis, concomitant medications, IGRA conversion and anti-TNF alpha, including type and treatment duration. The median duration of anti-TNF alpha was 21.5 months, and the median age was 35.3 yr. Of the 127 patients, IGRA conversion was found in 10 patients (7.9%). There was no significant variation between IGRA conversion rate and any risk factors except for age. IGRA conversion rate was not significantly different between AS and rheumatoid arthritis (P = 0.12). IGRA conversion was observed in AS patients receiving anti-TNF alpha in Korea. A follow-up IGRA test can be helpful for identifying LTBI or new tuberculosis in AS patients receiving anti-TNF alpha.
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