Metabolic tumor volume by positron emission tomography/computed tomography as a clinical parameter to determine therapeutic modality for early stage Hodgkin's lymphoma.
- Authors
- Song, Moo Kon; Chung, Joo-Seop; Lee, Je-Jung; Jeong, Shin Young; Lee, Sang-Min; Hong, Jun-Shik; Chong, Ari; Moon, Joon-Ho; Kim, Ji-Hyun; Lee, Seok-Mo; Kim, Seong Jang; Shin, Ho-Jin
- Issue Date
- Dec-2013
- Publisher
- WILEY-BLACKWELL
- Citation
- CANCER SCIENCE, v.104, no.12, pp.1656 - 1661
- Indexed
- SCIE
SCOPUS
- Journal Title
- CANCER SCIENCE
- Volume
- 104
- Number
- 12
- Start Page
- 1656
- End Page
- 1661
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161128
- DOI
- 10.1111/cas.12282
- ISSN
- 1347-9032
- Abstract
- Recent studies have shown that metabolic tumor volume (MTV) by positron emission tomography/computed tomography (PET/CT) is an important prognostic parameter in patients with non-Hodgkin's lymphoma. However, it is unknown whether doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) alone in early stage Hodgkin's lymphomawould lead to similar disease control as combined modality therapy (CMT) using MTV by PET/CT. One hundred and twenty-seven patients with early stage Hodgkin's lymphoma who underwent PET/CT at diagnosis were enrolled. The MTV was delineated on PET/CT by the area = SUVmax, 2.5 (standardized uptake value [SUV]). Sixty-six patients received six cycles of ABVD only. The other 61 patients received CMT (involved-field radiotherapy after 4-6 cycles of ABVD). The calculatedMTV cut-off value was 198 cm(3). Clinical outcomes were compared according to several prognostic factors (i.e. age = 50 years, male, performance status = 2, stage II, B symptoms, = 4 involved sites, extranodal site, large mediastinal mass, CMT, elevated erythrocyte sedimentation rate and high MTV). Older age (progression-free survival [PFS], P = 0.003; overall survival [OS], P = 0.007), B symptoms (PFS, P = 0.006; OS, P = 0.036) and high MTV (PFS, P = 0.008; OS, P = 0.007) were significant independent prognostic factors. Survival of two high MTV groups treated with ABVD only and CMT were lower than the low MTV groups (PFS, P < 0.012; OS, P < 0.045). ABVD alone was sufficient to control disease in those with low MTV status. However, survival was poor, even if the CMT was assigned a high MTV status. The MTV would be helpful for deciding the therapeutic modality in patients with early stage Hodgkin's lymphoma.
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