Influence ofAPOE Genotype on Whole-Brain Functional Networks in Cognitively Normal Elderly
DC Field | Value | Language |
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dc.contributor.author | Seo, Eun Hyun | - |
dc.contributor.author | Lee, Dong Young | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Park, Jun-Sung | - |
dc.contributor.author | Sohn, Bo Kyung | - |
dc.contributor.author | Choe, Young Min | - |
dc.contributor.author | Byun, Min Soo | - |
dc.contributor.author | Choi, Hyo Jung | - |
dc.contributor.author | Woo, Jong Inn | - |
dc.date.accessioned | 2022-07-16T07:08:56Z | - |
dc.date.available | 2022-07-16T07:08:56Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161331 | - |
dc.description.abstract | This study aimed to investigate the influence of apolipoprotein E (APOE) epsilon 4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE epsilon 4 carriers (epsilon 4+) and 58 non-carriers (epsilon 4-)] underwent clinical evaluation and resting [F-18] fluorodeoxyglucose positron emission tomography scan. Whole-brain functional networks were constructed from correlations of the 90 regions of interest using the automated anatomical labeling template, and analyzed using graph theoretical approaches. The overall small-world property seen in epsilon 4- was preserved in epsilon 4+. However, both local clustering and path length were lower in epsilon 4+ compared to epsilon 4-. In terms of the hubs of functional networks, epsilon 4+ showed decreased centrality of the right hippocampus but increased centrality of several brain regions associated with the default mode network compared to epsilon 4-. Our results indicate that genetic vulnerability to Alzheimer's disease may alter whole-brain functional networks even before clinical symptoms appear. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Influence ofAPOE Genotype on Whole-Brain Functional Networks in Cognitively Normal Elderly | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Min | - |
dc.identifier.doi | 10.1371/journal.pone.0083205 | - |
dc.identifier.scopusid | 2-s2.0-84892622581 | - |
dc.identifier.wosid | 000328730300139 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.8, no.12, pp.1 - 9 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | APOLIPOPROTEIN-E EPSILON-4 | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | GRAPH-THEORETICAL ANALYSIS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | GENETIC RISK | - |
dc.subject.keywordPlus | TOPOLOGICAL PATTERNS | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | ALLELE | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083205 | - |
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