Influence ofAPOE Genotype on Whole-Brain Functional Networks in Cognitively Normal Elderlyopen access
- Authors
- Seo, Eun Hyun; Lee, Dong Young; Lee, Jong-Min; Park, Jun-Sung; Sohn, Bo Kyung; Choe, Young Min; Byun, Min Soo; Choi, Hyo Jung; Woo, Jong Inn
- Issue Date
- Dec-2013
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.8, no.12, pp.1 - 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLOS ONE
- Volume
- 8
- Number
- 12
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161331
- DOI
- 10.1371/journal.pone.0083205
- ISSN
- 1932-6203
- Abstract
- This study aimed to investigate the influence of apolipoprotein E (APOE) epsilon 4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE epsilon 4 carriers (epsilon 4+) and 58 non-carriers (epsilon 4-)] underwent clinical evaluation and resting [F-18] fluorodeoxyglucose positron emission tomography scan. Whole-brain functional networks were constructed from correlations of the 90 regions of interest using the automated anatomical labeling template, and analyzed using graph theoretical approaches. The overall small-world property seen in epsilon 4- was preserved in epsilon 4+. However, both local clustering and path length were lower in epsilon 4+ compared to epsilon 4-. In terms of the hubs of functional networks, epsilon 4+ showed decreased centrality of the right hippocampus but increased centrality of several brain regions associated with the default mode network compared to epsilon 4-. Our results indicate that genetic vulnerability to Alzheimer's disease may alter whole-brain functional networks even before clinical symptoms appear.
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