Diagnostic and Prognostic Relevance of MMP-11 Expression in the Stromal Fibroblast-Like Cells Adjacent to Invasive Ductal Carcinoma of the Breast
- Authors
- Min, Kyueng-Whan; Kim, Dong-Hoon; Do, Sung-Im; Pyo, Jung-Soo; Kim, Kyungeun; Chae, Seoung Wan; Sohn, Jin Hee; Oh, Young-Ha; Kim, Hong Joo; Choi, Seon Hyeong; Choi, Yoon Jung; Park, Chan Heun
- Issue Date
- Dec-2013
- Publisher
- SPRINGER
- Citation
- ANNALS OF SURGICAL ONCOLOGY, v.20, no.suppl3, pp.S433 - S442
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF SURGICAL ONCOLOGY
- Volume
- 20
- Number
- suppl3
- Start Page
- S433
- End Page
- S442
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161352
- DOI
- 10.1245/s10434-012-2734-3
- ISSN
- 1068-9265
- Abstract
- Background. Matrix metalloproteinase 11 (MMP-11) is a matrix degrading enzyme known to be involved in the remodeling of extracellular matrix proteins. This enzyme recently has been reported to play a key role in tumor progression and results in poor clinical outcomes for several different types of tumors. Methods. A total of 192 patients diagnosed with invasive ductal carcinoma between 2000 and 2005 were included in this study. MMP-11 expression in tumors and stromal fibroblast-like cells was analyzed by immunohistochemical staining on a tissue microarray. Subsequently, evaluation of the associations between MMP-11 expression and clinicopathological characteristics was performed. Results. MMP-11 expression of stromal fibroblast-like cells was correlated with prognostic factors, including tumor size, metastasis, histological grade, central tumor fibrosis, p53 expression, and luminal A subtype and was linked to therapeutic markers, such as ER and HER2 (all p < 0.05). There was a significant relationship between worse overall survival and MMP-11 expression in both tumors and stromal fibroblast-like cells (all p < 0.05). In multivariate analysis, MMP-11 expression of stromal fibroblast-like cells was still significantly associated with poor prognosis (p = 0.043). Conclusions. MMP-11 expression was significantly related to clinicopathological parameters, which may be essential to the prediction of disease outcome in patients with invasive ductal carcinoma of the breast.
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