Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Gout
DC Field | Value | Language |
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dc.contributor.author | Son, Chang-Nam | - |
dc.contributor.author | Bang, So-Young | - |
dc.contributor.author | Kim, Ji Hae | - |
dc.contributor.author | Choi, Chan-Bum | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Jun, Jae-Bum | - |
dc.date.accessioned | 2022-07-16T08:26:22Z | - |
dc.date.available | 2022-07-16T08:26:22Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162019 | - |
dc.description.abstract | Activation of caspase-1 by NALP3 inflammasomes has been shown to be important in initiating acute gouty arthritis. The objectives of this study were to measure the levels of caspase-1 in synovial fluid in gout and various arthritides, and to elucidate the clinical significance of caspase-1 levels in synovial fluid. Caspase-1, IL-1 beta, IL-18, and uric acid were measured in synovial fluid from 112 patients with gout and other arthritides, such as rheumatoid arthritis, osteoarthritis, and spondyloarthropathy. Caspase-1 in synovial fluid from patients with crystal-induced arthritis, inflammatory arthritis, osteoarthritis, and spondyloarthropathy was 35.9 +/- 86.7, 49.7 +/- 107.7, 2.1 +/- 7.0, and 152.6 +/- 155.7 pg/mL, respectively. The mean level and the frequency of high levels (>= 125 pg/mL) of caspase-1 in spondyloarthropathy were significantly higher than those in the other arthritides including gout. Caspase-1 was detectible in the synovial fluid of patients with the various arthritides. Contrary to our hypothesis, the caspase-1 level in the synovial fluid of patients with gout was not higher than in that of other arthritides. High levels of caspase-1 may be helpful in differentiating spondyloarthropathy from other arthritides. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Gout | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, So-Young | - |
dc.contributor.affiliatedAuthor | Choi, Chan-Bum | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.contributor.affiliatedAuthor | Jun, Jae-Bum | - |
dc.identifier.doi | 10.3346/jkms.2013.28.9.1289 | - |
dc.identifier.scopusid | 2-s2.0-84884385439 | - |
dc.identifier.wosid | 000324547000005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.28, no.9, pp.1289 - 1292 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 28 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1289 | - |
dc.citation.endPage | 1292 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001802017 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | SCAVENGER RECEPTOR CD163 | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | ANKYLOSING-SPONDYLITIS | - |
dc.subject.keywordPlus | NALP3 INFLAMMASOME | - |
dc.subject.keywordPlus | REVISED CRITERIA | - |
dc.subject.keywordPlus | URIC-ACID | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | OSTEOARTHRITIS | - |
dc.subject.keywordAuthor | Caspase-1 | - |
dc.subject.keywordAuthor | Synovial Fluid | - |
dc.subject.keywordAuthor | Gout | - |
dc.subject.keywordAuthor | Spondyloarthropathies | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2013.28.9.1289 | - |
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