Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Goutopen access
- Authors
- Son, Chang-Nam; Bang, So-Young; Kim, Ji Hae; Choi, Chan-Bum; Kim, Tae-Hwan; Jun, Jae-Bum
- Issue Date
- Sep-2013
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Caspase-1; Synovial Fluid; Gout; Spondyloarthropathies
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.28, no.9, pp.1289 - 1292
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 28
- Number
- 9
- Start Page
- 1289
- End Page
- 1292
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162019
- DOI
- 10.3346/jkms.2013.28.9.1289
- ISSN
- 1011-8934
- Abstract
- Activation of caspase-1 by NALP3 inflammasomes has been shown to be important in initiating acute gouty arthritis. The objectives of this study were to measure the levels of caspase-1 in synovial fluid in gout and various arthritides, and to elucidate the clinical significance of caspase-1 levels in synovial fluid. Caspase-1, IL-1 beta, IL-18, and uric acid were measured in synovial fluid from 112 patients with gout and other arthritides, such as rheumatoid arthritis, osteoarthritis, and spondyloarthropathy. Caspase-1 in synovial fluid from patients with crystal-induced arthritis, inflammatory arthritis, osteoarthritis, and spondyloarthropathy was 35.9 +/- 86.7, 49.7 +/- 107.7, 2.1 +/- 7.0, and 152.6 +/- 155.7 pg/mL, respectively. The mean level and the frequency of high levels (>= 125 pg/mL) of caspase-1 in spondyloarthropathy were significantly higher than those in the other arthritides including gout. Caspase-1 was detectible in the synovial fluid of patients with the various arthritides. Contrary to our hypothesis, the caspase-1 level in the synovial fluid of patients with gout was not higher than in that of other arthritides. High levels of caspase-1 may be helpful in differentiating spondyloarthropathy from other arthritides.
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