Pre-Engraftment Syndrome after Unrelated Cord Blood Transplantation: A Predictor of Engraftment and Acute Graft-versus-Host Disease
- Authors
- Park, Meerim; Lee, Soo Hyun; Lee, Young Ho; Yoo, Keon Hee; Sung, Ki Woong; Koo, Hong Hoe; Kang, Hyoung Jin; Park, Kyung Duk; Shin, Hee Young; Ahn, Hyo Seop; Chung, Nak Gyun; Cho, Bin; Kim, Hack Ki; Koh, Kyung Nam; Im, Ho Joon; Seo, Jong Jin; Han, Dong Kyun; Baek, Hee Jo; Kook, Hoon; Hwang, Tai Ju; Lee, Eun Kyung; Hah, Jeong Ok; Lim, Yeon Jung; Jung, Hyun Joo; Park, Jun Eun; Jang, Moon Ju; Chong, So Young; Oh, Doyeun
- Issue Date
- Apr-2013
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Pre-engraftment syndrome; Cord blood transplantation; Risk factor; Outcome
- Citation
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, v.19, no.4, pp.640 - 646
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Volume
- 19
- Number
- 4
- Start Page
- 640
- End Page
- 646
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163064
- DOI
- 10.1016/j.bbmt.2013.01.014
- ISSN
- 1083-8791
- Abstract
- Pre-engraftment syndrome (PES) is poorly characterized, and its clinical significance and the prognostic impact after unrelated cord blood transplantation (CBT) are unclear. To address these issues, we retrospectively analyzed the incidence, risk factors, and clinical outcomes of PES in unrelated CBT recipients. Data of 381 patients who received unrelated CBT from 18 medical centers in Korea were reviewed. PES was defined as unexplained fever >38.3 degrees C not associated with infection, and/or unexplained skin rash with or without evidence of fluid retention before neutrophil recovery. PES developed in 102 patients (26.8%) at a median of 7 days after CBT. Of these patients, 74 patients (72.5%) received intravenous corticosteroid at a median dose of 1 mg/kg/day, and of these, 95% showed clinical improvement. Risk factors for developing PES included low risk disease, myeloablative conditioning, graft-versus-host disease (GVHD) prophylaxis without methotrexate or corticosteroid, and >5.43 x 10(7)/kg infused nucleated cells. Absence of PES was one of the risk factors for graft failure in multivariate analysis. The cumulative incidence of grade II to grade IV acute GVHD by 100 days after CBT was higher in patients with PES than in those without PES (56.0% versus 34.4%, P < .01). PES was not associated with chronic GVHD, treatment-related mortality, relapse, or overall survival. PES seems to be common after CBT and may be associated with enhanced engraftment without significant morbidity.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 소아청소년과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163064)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.