Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization
- Authors
- Oh, Yohan; Chung, Kwang Chul
- Issue Date
- Jan-2013
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- ZNF131; Estrogen signaling; ER alpha; Repressor; Receptor dimerization
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.430, no.1, pp.400 - 405
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 430
- Number
- 1
- Start Page
- 400
- End Page
- 405
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163591
- DOI
- 10.1016/j.bbrc.2012.11.031
- ISSN
- 0006-291X
- Abstract
- Steroid hormone estrogen elicits various physiological functions, many of which are mediated through two structurally and functionally distinct estrogen receptors, ER alpha and ER beta. The functional role of zinc finger protein 131 (ZNF131) is poorly understood, but it is assumed to possess transcriptional regulation activity due to the presence of a DNA binding motif. A few recent reports, including ours, revealed that ZNF131 acts as a negative regulator of ER alpha and that SUMO modification potentiates the negative effect of ZNF131 on estrogen signaling. However, its molecular mechanism for ER alpha, inhibition has not been elucidated in detail. Here, we demonstrate that ZNF131 directly interacts with ER alpha, which consequently inhibits ER alpha-mediated trans-activation by suppressing its homo-dimerization. Moreover, we show that the C-terminal region of ZNF131 containing the SUMOylation site is necessary for its inhibition of estrogen signaling. Taken together, these data suggest that ZNF131 inhibits estrogen signaling by acting as an ER alpha-co-repressor.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163591)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.