Clinical value of metabolic tumor volume by PET/CT in extranodal natural killer/T cell lymphoma
- Authors
- Song, Moo Kon; Chung, Joo-Seop; Shin, Ho-Jin; Moon, Joon-Ho; Ahn, Jae-Sook; Lee, Ho-Sup; Lee, Sang-Min; Lee, Gyeong-Won; Kim, Seong-Jang; Lee, Seok-Mo
- Issue Date
- Jan-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Lymphoma; Positron emission tomography; Radiotherapy
- Citation
- LEUKEMIA RESEARCH, v.37, no.1, pp.58 - 63
- Indexed
- SCIE
SCOPUS
- Journal Title
- LEUKEMIA RESEARCH
- Volume
- 37
- Number
- 1
- Start Page
- 58
- End Page
- 63
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163592
- DOI
- 10.1016/j.leukres.2012.09.011
- ISSN
- 0145-2126
- Abstract
- This study investigated whether metabolic tumor volume (MTV) by PET/CT as indicator of extent of lymphoma burden would be a prognostic factor in stage IE/IIE extranodal natural killer/T cell lymphoma (ENKTCL). Eighty patients with stage I-E/IIE ENKTCL in the upper aerodigestive tract underwent PET/CT at diagnosis were enrolled and 32 patients received upfront radiotherapy (RTx). MTV was measured on PET/CT images by the extranodal region above SUV, 2.5. Receiver operating curve analyses indicated that an MTV of 35.2 cm(3) was the ideal cut-off to distinguish between low and high MTV groups. Clinical outcomes were compared according to several prognostic factors (age, stage, high performance status [PS], high International Prognostic Index, elevated lactate dehydrogenase [LDH], local tumor invasiveness [LTI], high MTV and up-front RT). High PS, elevated LDH, LTI, high MTV and upfront RT were associated with survivals. In multivariate analysis, high MTV (PFS, HR = 4.170, 95% CI = 1.714-10.147, p = 0.002; OS, HR = 4.102, 95% CI = 1.617-10.408, p = 0.003) and up-front RT (PFS, HR = 0.410, 95% CI = 0.178-0.946, p = 0.037; OS, HR = 0.365, 95% CI = 0.152-0.872, p = 0.023) were significant independent prognostic factors. Upfront RTx and extent of tumor burden, as measured by the MTV, had significant prognostic value in patients with ENKTCL.
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