Effect of Mycophenolic Acid on Cyclosporin A-Induced Fibronectin Expression in Rat Mesangial Cells
- Authors
- Park, Joon-Sung; Kim, Gheun-Ho; Jo, Chor Ho; Kim, Sua; Lee, Chang Hwa; Kim, Yong Soo; Kang, Chong Myung
- Issue Date
- 2013
- Publisher
- KARGER
- Keywords
- Cyclosporin; Fibrosis; Transforming growth factor-beta; Smad proteins
- Citation
- PHARMACOLOGY, v.91, no.1-2, pp.20 - 28
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMACOLOGY
- Volume
- 91
- Number
- 1-2
- Start Page
- 20
- End Page
- 28
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163817
- DOI
- 10.1159/000343764
- ISSN
- 0031-7012
- Abstract
- This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of cyclosporin A (CsA) and, if so, to determine the molecular mechanisms involved. The effect of MPA treatment on CsA-induced signaling through the transforming growth factor-beta (TGF-beta)/Smad pathway was evaluated by immunoblot analysis in cultured primary rat mesangial cells. Treatment of cells with 1 mu mol/l MPA did not significantly decrease the CsA-induced expression of TGF-beta(1), but partially reversed the increases in Smad3 phosphorylation and fibronectin (FBN) production, and increased Smad7 expression. These results suggest that MPA may ameliorate CsA-induced FBN production by modulating the Smad signaling pathway. This study provides evidence that MPA can attenuate CsA-induced renal injury after kidney transplantation.
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