A three-year follow-up of intravitreal triamcinolone acetonide injection and macular laser photocoagulation for diffuse diabetic macular edema.open access
- Authors
- Cho, Hee Yoon; Kang, Se Woong; Kim, Yun Taek; Chung, Song Ee; Lee, Seung Woo
- Issue Date
- Oct-2012
- Publisher
- The Korean Ophthalmological Society
- Keywords
- Diabetic retinopathy; Intravitreal injections; Laser therapy; Macular edema; Triamcinolone
- Citation
- Korean journal of ophthalmology : KJO, v.26, no.5, pp.362 - 368
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean journal of ophthalmology : KJO
- Volume
- 26
- Number
- 5
- Start Page
- 362
- End Page
- 368
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164498
- DOI
- 10.3341/kjo.2012.26.5.362
- ISSN
- 1011-8942
- Abstract
- To report the three-year outcomes of macular laser photocoagulation following intravitreal injection of triamcinolone acetonide (IVTA) for diffuse diabetic macular edema (DME). A prospective, randomized controlled study was completed. Eighty-six eyes of 74 patients with diffuse DME were randomized into two groups. Eyes assigned to the combination group (n = 48) were subjected to macular laser photocoagulation three weeks after IVTA. Eyes in the IVTA group (n = 38) underwent IVTA alone. Central macular thickness was measured by optical coherence tomography, and the number of additional treatments and mean time to recurrence were assessed. Thirty-seven eyes in the combination group and 26 eyes in the IVTA group completed the three-year follow-up. Recurrence of DME after initial treatment was not observed for nine of the 37 (24.3%) eyes in the combination group or for one of the 26 (3.9$) eyes in the IVTA group (p = 0.028). DME was absent for 19.9 months after treatment in the combination group compared to 10.3 months in the IVTA group (p = 0.027). The mean number of additional treatments was 0.92 in the combination group and 1.88 in the IVTA group (p = 0.001). Results in the subset of subjects who completed the three-year follow-up demonstrated that laser photocoagulation following IVTA is more effective than IVTA monotherapy for diffuse DME. Combination therapy required fewer additional treatments and resulted in a lower recurrence rate than IVTA monotherapy.
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