Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas
- Authors
- Jang, Se Min; Han, Hulin; Jun, Young Jin; Jang, Si-Hyong; Min, Kyueng-Whan; Sim, Jongmin; Ahn, Hye In; Lee, Kang Hong; Jang, Ki-Seok; Paik, Seung Sam
- Issue Date
- Oct-2012
- Publisher
- BMJ PUBLISHING GROUP
- Citation
- JOURNAL OF CLINICAL PATHOLOGY, v.65, no.10, pp.902 - 906
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL PATHOLOGY
- Volume
- 65
- Number
- 10
- Start Page
- 902
- End Page
- 906
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164558
- DOI
- 10.1136/jclinpath-2012-200730
- ISSN
- 0021-9746
- Abstract
- Aims Cell adhesion molecule 4 (CADM4) is a novel tumour suppressor. The purpose of this study was to investigate the correlation between its expression and the expression of E-cadherin and Ki-67 in colorectal adenocarcinomas, as well as its effect on patient survival. Methods We evaluated CADM4 expression in tissue microarrays of 513 colorectal adenocarcinomas by immunohistochemistry. Results CADM4 was highly expressed in 210 of the 513 colorectal adenocarcinomas; expression was reduced in 185 cases and absent in the remaining cases. Loss of CADM4 expression was correlated with larger tumour size (6.2 +/- 2.1 cm vs 5.3 +/- 2.0 cm, p<0.001), mucinous tumour type (61.5% vs 20.9%, p<0.001), lymph node metastasis (31.4% vs 20.9%, p=0.022), higher Dukes stage (25.5% vs 19.6%, p=0.044), poorer differentiation (38.5% vs 18.8%, p<0.001), absence of E-cadherin expression (28.5% vs 16.0%, p=0.007) and presence of Ki-67 expression (27.3% vs 12.3%, p<0.001). In univariable Cox regression analysis, absence of CADM4 expression was associated with poorer overall survival (HR 0.712; 95% CI 0.512 to 0.989, p=0.042) and disease-free survival (HR 0.732; 95% CI 0.546 to 0.981, p=0.037). In multivariate analysis with the Cox proportional hazards model, CADM4 expression was not an independent prognostic factor of overall survival (HR 0.726; 95% CI 0.516 to 1.021, p=0.066) and disease-free survival (HR 0.762; 95% CI 0.563 to 1.033, p=0.080). Conclusions Loss of CADM4 expression is relatively frequent in colorectal adenocarcinomas and may play an important role in cancer progression and patient survival.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 외과학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 병리학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164558)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.