Fatal Varicella-Zoster Virus Vasculopathy Associated With Adalimumab Therapy
- Authors
- Baek, Wonki; Lee, Sang-Gon; Kim, Young Seo; Kim, Jae-Hoon; Jun, Jae-Bum; Kim, Hyun Young
- Issue Date
- Sep-2012
- Publisher
- AMER MEDICAL ASSOC
- Citation
- ARCHIVES OF NEUROLOGY, v.69, no.9, pp.1193 - 1196
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARCHIVES OF NEUROLOGY
- Volume
- 69
- Number
- 9
- Start Page
- 1193
- End Page
- 1196
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164807
- DOI
- 10.1001/archneurol.2011.3741
- ISSN
- 0003-9942
- Abstract
- Objective: To describe the case of a patient who had been receiving adalimumab for rheumatoid arthritis and died of varicella-zoster virus vasculopathy with multifocal cerebral hemorrhage. Design: Case report. Setting: Hanyang University Hospital, Seoul, Republic of Korea. Patient: A 66-year-old woman with adalimumab therapy for rheumatoid arthritis followed by stuporous mental changes. Results: Magnetic resonance imaging scans showed multifocal parenchymal lesions and hemorrhage in the brainstem and supratentorial areas. Polymerase chain reaction analysis of the cerebrospinal fluid was positive for varicella-zoster virus. The patient died of multifocal vasculopathy despite intensive antiviral and antibacterial medication. Conclusions: Varicella-zoster virus multifocal vasculopathy with encephalitis may be associated with adalimumab therapy. Clinicians should be aware of the possibility of fatal varicella-zoster virus vasculopathy with encephalitis in patients undergoing adalimumab therapy for rheumatoid arthritis.
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