국내에서 지역사회 급성 신우신염 원인균의 항균제 감수성 결과에 근거하여 지역사회 급성 방광염 치료 항균제를 선택할 수 있는가?open accessIs it acceptable to select antibiotics for the treatment of community-acquired acute cystitis based on the antibiotics susceptibility results for uropathogens from community-acquired acute pyelonephritis in Korea?
- Other Titles
- Is it acceptable to select antibiotics for the treatment of community-acquired acute cystitis based on the antibiotics susceptibility results for uropathogens from community-acquired acute pyelonephritis in Korea?
- Authors
- Kim, Bongyoung; Kim, Jieun; Wie, Seong-heon; Park, Sun Hee; Cho, Young Kyun; Lim, Seung-Kwan; Shin, Sang Yop; Yum, Joon Sup; Lee, Jin Seo; Kweon, Ki Tae; Lee, Hyuck; Cheong, Hee Jin; Park, Dae Won; Ryu, Seong Yeol; Chung, Moon-Hyun; Pai, Hyunjoo
- Issue Date
- Aug-2012
- Publisher
- The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
- Keywords
- Antibiotic; Community; Cystitis; Pyelonephritis; Resistance
- Citation
- Infection and Chemotherapy, v.44, no.4, pp.269 - 274
- Indexed
- SCOPUS
KCI
- Journal Title
- Infection and Chemotherapy
- Volume
- 44
- Number
- 4
- Start Page
- 269
- End Page
- 274
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164939
- DOI
- 10.3947/ic.2012.44.4.269
- ISSN
- 2093-2340
- Abstract
- Background: Uncomplicated acute cystitis (CA-UAC) is one of the most common infections treated with antibiotics in the community. However, few data on etiology of CA-UAC and its susceptibility to antibiotics are available, primarily because, in Korea, insurance does not allow reimbursement for microbiological evaluation of CA-UAC. However, microbiologic data on community-acquired uncomplicated acute pyelonephritis (CA-UAPN) are available. The objective of the study was to evaluate the question of whether microbiologic data on CA-UAPN can be used for treatment of CA-UAC; therefore, etiology and antimicrobial susceptibility were compared between pathogens of CA-UAC and those of CA-UAPN. Materials and Methods: During 2008, 538 CA-UACs and 1,265 CA-UAPNs were recruited retrospectively from 14 hospitals (UTI research group). Microbiologic data on etiology and susceptibility to antibiotics were collected retrospectively. Results: Urine culture was positive in 131 CA-UACs (131/469, 27.9%) and 719 CA-UAPNs (719/1249, 57.6%). Escherichia coli was the most common pathogen in both groups [83.2% (109/131) in CA-UAC vs. 91.9% (661/719) in CA-UAPN]. Susceptibility to common UTI regimens, such as ciprofloxacin, extended-spectrum cephalosporins, and trimethoprim/sulfamethoxazole did not differ between urinary pathogens of CA-UACs and CA-UAPNs, however, a significant difference was observed in rates of resistance to ampicillin/sulbactam (16.5% vs. 42.9%, P<0.001, respectively). Conclusions: Rates of resistance of E. coli from CA-UAC and CA-UAPN to most antibiotics did not differ. For proper treatment, further microbiological evaluation for CA-UAC is mandatory.
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