Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-gamma in mice fed a high-fat diet
DC Field | Value | Language |
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dc.contributor.author | Park, Ji Heon | - |
dc.contributor.author | Lee, Sun Hee | - |
dc.contributor.author | Chung, Ill-Min | - |
dc.contributor.author | Park, Yongsoon | - |
dc.date.accessioned | 2022-07-16T14:22:32Z | - |
dc.date.available | 2022-07-16T14:22:32Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164974 | - |
dc.description.abstract | This study investigated the hypothesis that a sorghum extract exerts anti-diabetic effects through a mechanism that improves insulin sensitivity via peroxisome proliferator-activated receptor gamma (PPAR-gamma) from adipose tissue. Seven C57BL/6 mice were fed an AIN-93M diet with fat consisting of 10% of total energy intake (LF) for 14 weeks, and 21 mice were fed a high-fat AIN diet with 60% of calories derived from fat (HF). From week 8, the HF diet-fed mice were orally administered either saline (HF group), 0.5% (0.5% SE group), or 1% sorghum extract (1% SE group) for 6 weeks (n = 7/group). Perirenal fat content was significantly lower in the 0.5% SE and 1% SE groups than that in the HF mice. Levels of total and low-density lipoprotein cholesterol, triglycerides, glucose, and the area under the curve for glucose were significantly lower in mice administered 0.5% SE and 1% SE than those in HF mice. Serum insulin level was significantly lower in mice administered 1% SE than that in HF mice or those given 0.5% SE. PPAR-gamma expression was significantly higher, whereas the expression of tumor necrosis factor-a was significantly lower in mice given 1% SE compared to those in the HF mice. Adiponectin expression was also significantly higher in mice given 0.5% SE and 1% SE than that in the HF mice. These results suggest that the hypoglycemic effect of SE may be related with the regulation of PPAR-gamma-mediated metabolism in this mouse model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.title | Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-gamma in mice fed a high-fat diet | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.4162/nrp.2012.6.4.322 | - |
dc.identifier.scopusid | 2-s2.0-84866903784 | - |
dc.identifier.wosid | 000308569500007 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.6, no.4, pp.322 - 327 | - |
dc.relation.isPartOf | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 6 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 322 | - |
dc.citation.endPage | 327 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001691543 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | GREEN TEA EXTRACT | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MILLET | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordAuthor | Glucose metabolism | - |
dc.subject.keywordAuthor | mice | - |
dc.subject.keywordAuthor | PPAR-gamma | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | sorghum extract | - |
dc.identifier.url | https://e-nrp.org/DOIx.php?id=10.4162/nrp.2012.6.4.322 | - |
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