N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test
DC Field | Value | Language |
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dc.contributor.author | Park, Yongsoon | - |
dc.contributor.author | Moon, Hyoun-Jung | - |
dc.contributor.author | Kim, Seok-Hyeon | - |
dc.date.accessioned | 2022-07-16T14:23:48Z | - |
dc.date.available | 2022-07-16T14:23:48Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164986 | - |
dc.description.abstract | Epidemiological data and clinical trials suggest that n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have preventive and therapeutic effects on depression; however, the underlying mechanism remains elusive. The present study aimed to examine the behavioral effects and antidepressant mechanism of n-3 PUFA using a forced swimming test. Eleven-week-old male Sprague Dawley rats were fed an American Institute of Nutrition-93M diet containing 0%, 0.5% or 1% EPA and DHA relative to the total energy intake in their diet for 12 weeks (n=8 per group). Total dietary intake, body weight and hippocampus weights were not significantly different among groups. The groups administered 0.5% and 1% EPA+DHA diets had significantly higher levels of n-3 PUFA in their brain phospholipids compared to those in the control group. The immobility time was significantly decreased and the climbing time was significantly increased in the 0.5% and 1% EPA+DHA groups compared with those in the 0% EPA+DHA group. Plasma serotonin concentration and hippocampus c-AMP response element binding protein (CREB) expression were significantly increased in the 0.5% and 1% EPA+DHA groups compared with those in the 0% EPA+DHA group. Conversely, interleukin (IL)-6 expression was significantly reduced in the 0.5% and 1% EPA+DHA groups compared with that in the 0% EPA+DHA group. However, there were no dose-dependent effects of n-3 PUFA and no significant differences in expressions of IL-1 beta, tumor necrosis factor-alpha, brain-derived neurotrophic factor or phosphorylated CREB. In conclusion, long-term intake of EPA+DHA induced antidepressant-like effects in rats and overexpression of CREB via decreased IL-6 expression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.contributor.affiliatedAuthor | Kim, Seok-Hyeon | - |
dc.identifier.doi | 10.1016/j.jnutbio.2011.04.018 | - |
dc.identifier.scopusid | 2-s2.0-84864002328 | - |
dc.identifier.wosid | 000306880100010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.23, no.8, pp.924 - 928 | - |
dc.relation.isPartOf | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.citation.title | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 924 | - |
dc.citation.endPage | 928 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | EICOSAPENTAENOIC ACID | - |
dc.subject.keywordPlus | MAJOR DEPRESSION | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | FEMALE RATS | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | NEUROTRANSMISSION | - |
dc.subject.keywordPlus | PHOSPHOLIPIDS | - |
dc.subject.keywordPlus | DEPRIVATION | - |
dc.subject.keywordAuthor | BDNF | - |
dc.subject.keywordAuthor | CREB | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Forced swimming test | - |
dc.subject.keywordAuthor | n-3 polyunsaturated fatty acids | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0955286311001458?via%3Dihub | - |
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