Enhancement of long-term angiogenic efficacy of adipose stem cells by delivery of FGF2
- Authors
- Lee, Tae-Jin; Bhang, Suk Ho; Yang, Hee Seok; La, Wan-Guen; Yoon, Hee Hun; Shin, Jung-Youn; Seong, Jun Yeup; Shin, Heungsoo; Kim, Byung-Soo
- Issue Date
- Jul-2012
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Citation
- MICROVASCULAR RESEARCH, v.84, no.1, pp.1 - 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- MICROVASCULAR RESEARCH
- Volume
- 84
- Number
- 1
- Start Page
- 1
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165146
- DOI
- 10.1016/j.mvr.2012.04.004
- ISSN
- 0026-2862
- Abstract
- Stem cell transplantation can induce neovascularization. Regenerated blood vessels should remain stable for a long-term period in order to function as new blood vessels in ischemic tissues. Here we show that local delivery of FGF2 enhances the long-term (12 weeks) angiogenic efficacy of human adipose-derived stem cells (hADSCs) implanted into mouse ischemic hindlimbs. Following transplantation of hADSCs into ischemic hindlimbs of mice, hADSC viability was significantly higher in the hADSC + FGF2 group at 4 and 12 weeks post-transplantation than in the hADSC only group. Furthermore, hADSCs produced higher levels of angiogenic growth factors (i.e., fibroblast growth factor 2, vascular endothelial growth factor, hepatocyte growth factor, and platelet-derived growth factor) at both time points. As a result, the density of arterioles in the ischemic hindlimb muscle was significantly higher in the hADSC + FGF2 group than in either hADSC or FGF2 only group at both time points. The number of arterioles with larger diameters was significantly greater in the hADSC + FGF2 group than in the other groups at 12 weeks, and increased in the hADSC + FGF2 group as the time period increased from 4 weeks to 12 weeks post-transplantation. This suggests that FGF2 delivery to hADSC transplantation sites enhances long-term angiogenic efficacy of hADSCs transplanted into ischemic tissues.
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