Licochalcone E has an antidiabetic effect
- Authors
- Park, Hong Gyu; Bak, Eun Jung; Woo, Gye-Hyeong; Kim, Jin Moon; Quan, Zhejiu; Kim, Jung Mogg; Yoon, Ho-Kun; Cheon, Seung Hoon; Yoon, Goo; Yoo, Yun-Jung; Na, Younghwa; Cha, Jeong-Heon
- Issue Date
- Jul-2012
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Licochalcone E; Adipocyte differentiation; Obesity; Diabetes
- Citation
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.23, no.7, pp.759 - 767
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Volume
- 23
- Number
- 7
- Start Page
- 759
- End Page
- 767
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165149
- DOI
- 10.1016/j.jnutbio.2011.03.021
- ISSN
- 0955-2863
- Abstract
- Licochalcone E (lico E) is a retrochalcone isolated from the root of Glycyrrhiza inflata. Retrochalcone compounds evidence a variety of pharmacological profiles, including anticancer, antiparasitic, antibacterial, antioxidative and superoxide-scavenging properties. In this study, we evaluated the biological effects of lico E on adipocyte differentiation in vitro and obesity-related diabetes in vivo. We employed 3T3-L1 preadipocyte and C3H10T1/2 stem cells for in vitro adipocyte differentiation study and diet-induced diabetic mice for in vivo study. The presence of lico E during adipogenesis induced adipocyte differentiation to a significant degree, particularly at the early induction stage. Licochalcone E evidenced weak, but significant, peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand-binding activity. Two weeks of lico E treatment lowered blood glucose levels and serum triglyceride levels in the diabetic mice. Additionally, treatment with lico E resulted in marked reductions in adipocyte size and increases in the mRNA expression levels of PPAR gamma in white adipose tissue (WAT). Licochalcone E was also shown to significantly stimulate Akt signaling in epididymal WAT. In conclusion, lico E increases the levels of PPAR gamma expression, at least in part, via the stimulation of Akt signals and functions as a PPAR gamma partial agonist, and this increased PPAR gamma expression enhances adipocyte differentiation and increases the population of small adipocytes, resulting in improvements in hyperglycemia and hyperlipidemia under diabetic conditions.
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