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Fabrication of nanopatterned surfaces for tissue engineering
- Authors
- Jeong, Eun Ju; Lee, Jin Wook; Yeon, Soo-Jeong; Lee, Jae-Won; Kwark, Young-Je; Rhee, Sang-Hoon; Park, Won Ho; Kim, Seung Hyun; Lee, Kuen Yong
- Issue Date
- Jul-2012
- Publisher
- IEEE
- Keywords
- block copolymer; nanopattern; nanotopography; polymer surface; self-assembly; tissue engineering
- Citation
- Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012, pp.1030 - 1033
- Indexed
- SCOPUS
- Journal Title
- Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
- Start Page
- 1030
- End Page
- 1033
- Abstract
- The surface nanotopography of polymer substrates is a critical factor to regulate cellular behavior in tissue engineering approaches. In this study, nanopatterned surfaces were generated via self-assembly of polystyrene-b- poly(ethylene oxide)/dodecylbenzenesulfonic acid complex systems to control preosteoblast phenotype in vitro. Polystyrene domain sizes under 100 nm strongly affected the adhesion, proliferation, and differentiation of preosteoblasts cultured on the surfaces, irrespective of the same center-to-center distance between the domains. This approach may provide a useful means to design and develop novel polymer substrates for tissue engineering applications.
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Related Researcher
- Lee, Kuen Yong
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)