장피부 누공을 동반한 베체트 장염 환자를 Adalimumab으로 치료한 1예A Case of Intestinal Behçet's Disease Complicated Enterocutanous Fistula with a Good Response to Adalimumab
- Other Titles
- A Case of Intestinal Behçet's Disease Complicated Enterocutanous Fistula with a Good Response to Adalimumab
- Authors
- 오일환; 김진옥; 변영재; 성윤경; 최찬범; 김태환; 전재범; 엄완식
- Issue Date
- Jun-2012
- Publisher
- 대한류마티스학회
- Keywords
- Behçet' s disease; Intestine; TNF-α; Adalimumab
- Citation
- 대한류마티스학회지, v.19, no.3, pp.147 - 151
- Indexed
- KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 19
- Number
- 3
- Start Page
- 147
- End Page
- 151
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165313
- DOI
- 10.4078/jrd.2012.19.3.147
- ISSN
- 2093-940X
- Abstract
- Behçet's disease (BD) is a multisystemic disorder, which is characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesion. Although intestinal involvement is an uncommon manifestation of the BD, it leads to a poor prognosis, as a result of a high complication, such as intestinal perforation, fistula formation, and massive hemorrhage. Intestinal BD has the tendency for the resistance to conventional medical treatment, and it often requires a surgical intervention because of severe complication. Although the causes of intestinal BD are unknown, some studies show that tumor necrosis factor Alpha (TNF-α) plays a key role in the pathogenesis of BD. Therefore, anti-TNF-α monoclonal antibody, such as adalimumab, is one of the useful treatment for refractory and relapsed intestinal BD. We describe a patient who had intestinal BD complicated enterocutanous fistula with a good response to adalimumab.
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