Probiotic suppression of the H-pylori-induced responses by conjugated linoleic acids in a gastric epithelial cell line
- Authors
- Hwang, Sung Wook; Kim, Nayoung; Kim, Jung Mogg; Huh, Chul Sung; Ahn, Young Tae; Park, Se Hoon; Shin, Cheol Min; Park, Ji Hyun; Lee, Mi Kyoung; Nam, Ryoung Hee; Lee, Hye Seung; Kim, Joo Sung; Jung, Hyun Chae; Song, In Sung
- Issue Date
- Jun-2012
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Helicobacter pylori; Probiotics; Conjugated linoleic acids; Interleukin-8; Tumor necrosis factor-alpha; Inducible nitric oxide synthase
- Citation
- PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, v.86, no.6, pp.225 - 231
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
- Volume
- 86
- Number
- 6
- Start Page
- 225
- End Page
- 231
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165398
- DOI
- 10.1016/j.plefa.2012.04.002
- ISSN
- 0952-3278
- Abstract
- Conjugated linoleic acids (CLA) produced by Lactobacillus acidophilus was reported to decrease the activation of nuclear factor-kappa B. CLA was suggested as one of the anti-inflammatory molecular mechanisms of probiotics. In the present study, the effects of CLA on H. pylori-induced multiple responses were evaluated. IL-8, TNF-alpha and iNOS were measured in mRNA and/or protein levels in AGS cells after pretreatment with CLA or CLA-containing conditioned medium (CM) produced by Lactobacillus acidophilus or Lactobacillus plantarum. The increased expressions of IL-8 mRNA/protein and TNF-alpha mRNA were significantly suppressed by pretreatment with CM or CLA. The levels of IL-8 protein and TNF-alpha mRNA were suppressed by CM pretreatment better than CLA. The expression of iNOS mRNA was also significantly inhibited by CM pretreatment. These results suggest that the suppression of multiple mediators by CLA-containing CM plays a key role in the anti-inflammatory and anti-carcinogenic effects of probiotics on H. pylori infection.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 미생물학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165398)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.