Fluorescently Labeled Nanoparticles Enable the Detection of Stem Cell-Derived Hepatocytes
- Authors
- Ha, Youngeun; Shin, Jin-sup; Lee, Dong Yun; Rhim, Taiyoun
- Issue Date
- Jun-2012
- Publisher
- Korean Chemical Society
- Keywords
- Liver cirrhosis; Mesenchymal stem cell transplantation; Fluorescently labeled nanoparticles; Hepatocyte-specific differentiation
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.6, pp.1983 - 1988
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 33
- Number
- 6
- Start Page
- 1983
- End Page
- 1988
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165459
- DOI
- 10.5012/bkcs.2012.33.6.1983
- ISSN
- 0253-2964
- Abstract
- Stem cell transplantation is emerging as a possible new treatment for liver cirrhosis, and recent animal studies have documented the benefits of stem cell therapy in a hepatic fibrosis model. However, the underlying mechanism of stem cell therapy is still unclear. Among the proposed mechanisms, the cell replacement mechanism is the oldest and most important, in which permanently damaged tissue can be replaced by normal tissue to restore function. In the present study, Cy5.5-labeled superparamagnetic iron oxide (SPIO) was used to label human mesenchymal stem cells. The uptake of fluorescently labeled nanoparticles enabled the detection and monitoring of the transplanted stem cells; therefore, we confirmed the direct incorporation and differentiation of SPIO into the hepatocyte-like transplanted stem cells by detecting human tyrosine aminotransferase (TAT), well-known enzymatic marker for hepatocyte-specific differentiation.
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