Dendrimer type bio-reducible polymer for efficient gene delivery
- Authors
- Nam, Hye Yeong; Nam, Kihoon; Lee, Minhyung; Kim, Sung Wan; Bull, David A.
- Issue Date
- Jun-2012
- Publisher
- ELSEVIER
- Keywords
- Bioreducible polymer; Dendrimer; Gene delivery; Transfection; Cytotoxicity
- Citation
- JOURNAL OF CONTROLLED RELEASE, v.160, no.3, pp.592 - 600
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CONTROLLED RELEASE
- Volume
- 160
- Number
- 3
- Start Page
- 592
- End Page
- 600
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165461
- DOI
- 10.1016/j.jconrel.2012.04.025
- ISSN
- 0168-3659
- Abstract
- Arginine-grafted bio-reducible poly(disulfide amine) (ABP) was incorporated into the poly(amido amine) (PAMAM) dendrimer, creating a high molecular weight bio-reducible polymer, PAM-ABP, to overcome the limitations of the low molecular weight ABP. The newly synthesized PAM-ABP was studied to determine its efficacy as a gene delivery carrier. The PAM-ABP demonstrated superior condensing ability for plasmid DNA through the formation of compact nanosized polyplexes. These compact polyplexes enhanced cellular uptake and were less susceptible to reducing agents, resulting in greater transfection efficiency compared to ABP alone. Based on these results, this newly developed PAM-ABP polyplex is a promising delivery system for clinical gene therapy.
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