Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injury
DC Field | Value | Language |
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dc.contributor.author | Kwon, Jae-Woo | - |
dc.contributor.author | Shin, Eun-Soon | - |
dc.contributor.author | Lee, Jong-Eun | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Jee, Young-Koo | - |
dc.contributor.author | Kim, Yoon-Keun | - |
dc.contributor.author | Park, Hae-Sim | - |
dc.contributor.author | Min, Kyung-Up | - |
dc.contributor.author | Park, Heung-Woo | - |
dc.date.accessioned | 2022-07-16T15:30:33Z | - |
dc.date.available | 2022-07-16T15:30:33Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165681 | - |
dc.description.abstract | Purpose: Drug-induced liver injury (DILI) is the most common adverse drug reaction; however, it is not easily predicted. We hypothesize that DILI has a common genetic basis. Based on the findings of previous animal studies on toxic hepatitis, we selected the thioredoxin reductase 1 gene (TXNRD1) as a candidate marker of DILI for this genetic association study. Methods: Records from 118 patients with DILI were extracted from the database of the Adverse Drug Reaction Research Group in South Korea. Causative drugs included antituberculosis drugs (n=68, 57.6%), antibiotics (n=22, 18.6%), antiepileptic drugs (n=7, 5.9%), non-steroidal anti-inflammatory drugs (n=5, 4.2%), and others (n=16, 13.7%). Seven single nucleotide polymorphisms (SNPs) in TXNRD1 (rs10735393, rs4964287, rs4595619, rs10861201, rs11111997, rs4246270, and rs4246271) were scored in 118 DILI patients and in 120 drug-matched controls without liver injury. Results: No differences were found between the frequencies of any of the 7 SNPs in the cases and controls; however, a significant association was found between a TTA haplotype composed of rs10735393, rs4964287, and rs4595619 and DILI using an allele model (odds ratio, 1.79; 95% confidence interval, 1.18-2.73; P=0.008; Bonferroni corrected P=0.024). Conclusions: These results suggest that genetic variations in TXNRD1 favor the development of DILI, although a larger confirmative study is needed. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.title | Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Heon | - |
dc.identifier.doi | 10.4168/aair.2012.4.3.132 | - |
dc.identifier.scopusid | 2-s2.0-84861769662 | - |
dc.identifier.wosid | 000303226200004 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.4, no.3, pp.132 - 136 | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 4 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 136 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001653300 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | S-TRANSFERASE M1 | - |
dc.subject.keywordPlus | INDUCED HEPATOTOXICITY | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | GENOTYPES | - |
dc.subject.keywordAuthor | Drug-induced liver injury | - |
dc.subject.keywordAuthor | genetic association study | - |
dc.subject.keywordAuthor | genetic polymorphism | - |
dc.subject.keywordAuthor | single nucleotide polymorphisms | - |
dc.subject.keywordAuthor | thioredoxin reductase 1 | - |
dc.identifier.url | https://e-aair.org/DOIx.php?id=10.4168/aair.2012.4.3.132 | - |
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