Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injuryopen access
- Authors
- Kwon, Jae-Woo; Shin, Eun-Soon; Lee, Jong-Eun; Kim, Sang-Heon; Kim, Sang-Hoon; Jee, Young-Koo; Kim, Yoon-Keun; Park, Hae-Sim; Min, Kyung-Up; Park, Heung-Woo
- Issue Date
- May-2012
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Drug-induced liver injury; genetic association study; genetic polymorphism; single nucleotide polymorphisms; thioredoxin reductase 1
- Citation
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.4, no.3, pp.132 - 136
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
- Volume
- 4
- Number
- 3
- Start Page
- 132
- End Page
- 136
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165681
- DOI
- 10.4168/aair.2012.4.3.132
- ISSN
- 2092-7355
- Abstract
- Purpose: Drug-induced liver injury (DILI) is the most common adverse drug reaction; however, it is not easily predicted. We hypothesize that DILI has a common genetic basis. Based on the findings of previous animal studies on toxic hepatitis, we selected the thioredoxin reductase 1 gene (TXNRD1) as a candidate marker of DILI for this genetic association study. Methods: Records from 118 patients with DILI were extracted from the database of the Adverse Drug Reaction Research Group in South Korea. Causative drugs included antituberculosis drugs (n=68, 57.6%), antibiotics (n=22, 18.6%), antiepileptic drugs (n=7, 5.9%), non-steroidal anti-inflammatory drugs (n=5, 4.2%), and others (n=16, 13.7%). Seven single nucleotide polymorphisms (SNPs) in TXNRD1 (rs10735393, rs4964287, rs4595619, rs10861201, rs11111997, rs4246270, and rs4246271) were scored in 118 DILI patients and in 120 drug-matched controls without liver injury. Results: No differences were found between the frequencies of any of the 7 SNPs in the cases and controls; however, a significant association was found between a TTA haplotype composed of rs10735393, rs4964287, and rs4595619 and DILI using an allele model (odds ratio, 1.79; 95% confidence interval, 1.18-2.73; P=0.008; Bonferroni corrected P=0.024). Conclusions: These results suggest that genetic variations in TXNRD1 favor the development of DILI, although a larger confirmative study is needed.
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