The association between the mannose-binding lectin codon 54 polymorphism and systemic lupus erythematosus: a meta-analysis update
- Authors
- Lee, Young Ho; Lee, Hye-Soon; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu
- Issue Date
- May-2012
- Publisher
- SPRINGER
- Keywords
- Mannose-binding lectin; Polymorphism; Systemic lupus erythematosus; Meta-analysis
- Citation
- MOLECULAR BIOLOGY REPORTS, v.39, no.5, pp.5569 - 5574
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BIOLOGY REPORTS
- Volume
- 39
- Number
- 5
- Start Page
- 5569
- End Page
- 5574
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165744
- DOI
- 10.1007/s11033-011-1361-6
- ISSN
- 0301-4851
- Abstract
- The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154-1.459, P = 1.4 x 10(-5)]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062-1.462, P = 0.007; OR = 1.268, 95% CI = 1.049-1.532, P = 0.014; OR = 1.939, 95% CI = 1.269-2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
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