Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asiansopen access
- Authors
- Li, Huaixin; Kilpeläinen, Tuomas; Liu, Chen; Zhu, Jingwen; Liu, Yun; Hu, Cheng; Yang, Zhen; Zhang, Weihua; Bao, Wei; Cha, Seongwon; Wu, Ying; Yang, Tuanming; Sekine, Akihiro; Choi, Boyoul; Yajnik, Chittaranjan Sakerlal; Zhou, Daizhan; Takeuchi, Fumihiko; Yamamoto, K.; Chan, Juliana C.N.; Mani, Kulathu Radha; Been, Latonya F.; Imamura, Minako; Nakashima, Eirtaro; Lee, Nanette R.; Fujisawa, Tomomi; Karasawa, Shigeru; Wen, Wanqing; Joglekar, Charudatta Vaman; Lu, Wei; Chang, Yi-Cheng; Xiang, Yongbing; Gao, Yutang; Liu, Simin; Song, Yiqing; Kwak, Soo-heon; Shin, Hyoungdoo; Park, Kyong Soo; Fall, Caroline H.D.; Kim, Jong Yeol; Sham, Pak Chung; Lam, Karen Siu Ling; Zheng, Wei; Shu, Xiaoou; Deng, Hongwen; Ikegami, Hiroshi; Krishnaveni, Ghattu V.; Sanghera, Dharambir Kaur; Chuang, Lee Ming; Liu, Liegang; Hu, Renming; Kim, Yu-mi; Daimon, Makoto; Hotta, Kikuko; Jia, Wei; Kooner, Jaspal Singh; Chambers, John Campbell; Ratan Chandak, Giriraj; Ma, Ronald; Maeda, Shiro; Dorajoo, R.; Yokota, Mitsuhiro; Takayanagi, R.; Kato, Norihiro; Lin Xuyun; Loos, R. J. F.
- Issue Date
- Apr-2012
- Publisher
- SPRINGER
- Keywords
- Asians; FTO; Meta-analysis; Obesity; Type 2 diabetes
- Citation
- DIABETOLOGIA, v.55, no.4, pp.981 - 995
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIABETOLOGIA
- Volume
- 55
- Number
- 4
- Start Page
- 981
- End Page
- 995
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165933
- DOI
- 10.1007/s00125-011-2370-7
- ISSN
- 0012-186X
- Abstract
- FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians. All studies published on the association between FTO-rs9939609 (or proxy [r (2) > 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes. The FTO-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 x 10(-19)), overweight by 1.13-fold/allele (p = 1.0 x 10(-11)) and type 2 diabetes by 1.15-fold/allele (p = 5.5 x 10(-8)). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p = 6.6 x 10(-5)). The FTO-rs9939609 minor allele increased BMI by 0.26 kg/m(2) per allele (p = 2.8 x 10(-17)), WHR by 0.003/allele (p = 1.2 x 10(-6)), and body fat percentage by 0.31%/allele (p = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12-20%) than South Asians (30-33%), the effect of FTO variation on obesity-related traits and type 2 diabetes was similar in the two populations. FTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, FTO is also associated with type 2 diabetes independently of BMI.
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